IRS4

Gene Symbol	IRS4
Entrez Gene	8471
Alt Symbol	IRS-4, PY160
Species	Human
Gene Type	protein-coding
Description	insulin receptor substrate 4
Other Description	160 kDa phosphotyrosine protein|phosphoprotein of 160 kDa|pp160
Swissprots	O14654
Accessions	EAX02682 O14654 AF007567 AAC51738 AL832136 BC156188 AAI56189 BC156977 AAI56978 HG512649 XM_005262220 XP_005262277 XM_006724713 XP_006724776 XM_011531061 XP_011529363 NM_003604 NP_003595
Function	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9553137}; Peripheral membrane protein {ECO:0000269|PubMed:9553137}; Cytoplasmic side {ECO:0000269|PubMed:9553137}.
Tissue Specificity	Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. {ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801}.
Top Pathways	Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, cGMP-PKG signaling pathway, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

IRS-4 (C-1) - sc-373778 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IRS-4 (C-19) - sc-8189 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IRS-4 (C-4) - sc-393207 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IRS-4 (H-300) - sc-28830 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IRS-4 (S-20) - sc-8190 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IRS-4 (RI-7) - sc-100854 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-IRS4 antibody - ab198009 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-IRS4 antibody - ab71154 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-IRS4 antibody - ab56477 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-IRS4 antibody [EP907Y] - ab52622 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP907Y

Anti-IRS4 Antibody (aa1240-1257) - LS-C8288 from LifeSpan Bioscience Prices $475.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-IRS4 Antibody - LS-C62244 from LifeSpan Bioscience Prices $305.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-IRS4 Antibody (aa633-647) - LS-C186534 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-IRS4 Antibody (clone 5B9) - LS-C198571 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B9

Anti-IRS4 Antibody (C-Terminus, clone EP907Y) - LS-C49913 from LifeSpan Bioscience Prices $450.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP907Y

IRS4 Antibody - NBP2-14130 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

IRS4 Antibody (5B9) - H00008471-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B9

IRS4 Antibody - H00008471-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-IRS4 (466-480) antibody produced in rabbit - SAB1105007 from Sigma-Aldrich Prices $279.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-IRS4 (1241-1255) antibody produced in rabbit - SAB1105008 from Sigma-Aldrich Prices $279.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-IRS4 antibody produced in mouse - WH0008471M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B9

Anti-IRS4 antibody produced in rabbit - HPA017372 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Phosphotyrosine Antibody - FITC Conjugated (OASA03628) - OASA03628 from Aviva Systems Biology Prices $600.00 Sizes 500 µg Host Mouse Clonality Monoclonal Clone PY20

Phosphotyrosine Antibody - PE Conjugated (OASA03630) - OASA03630 from Aviva Systems Biology Prices $510.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone PY20

IRS4-Antibody-monoclonal-M01 - AT2549a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B9

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