| Gene Symbol |
FGD1
|
| Entrez Gene |
2245
|
| Alt Symbol |
AAS, FGDY, MRXS16, ZFYVE3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FYVE, RhoGEF and PH domain containing 1
|
| Other Description |
FYVE, RhoGEF and PH domain-containing protein 1|faciogenital dysplasia 1 protein|rho/Rac GEF|rho/Rac guanine nucleotide exchange factor FGD1|zinc finger FYVE domain-containing protein 3
|
| Swissprots |
Q8N4D9 Q5H999 P98174
|
| Accessions |
EAW93179 EAW93180 EAW93181 P98174 AK226117 AK299635 BAG61561 BC034530 AAH34530 U11690 AAA57004 NM_004463 NP_004454
|
| Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with membrane ruffles and lamellipodia. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
|
| Top Pathways |
Regulation of actin cytoskeleton
|