| Gene Symbol |
FARP2
|
| Entrez Gene |
9855
|
| Alt Symbol |
FIR, FRG, PLEKHC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FERM, RhoGEF and pleckstrin domain protein 2
|
| Other Description |
FERM domain including RhoGEF|FERM, RhoGEF and pleckstrin domain-containing protein 2|FGD1-related Cdc42-GEF|PH domain-containing family C member 3|pleckstrin homology domain-containing family C member 3
|
| Swissprots |
F5GZ84 B7Z6J8 Q53QM5 Q8WU27 O94887 Q9UFE7
|
| Accessions |
AAY14682 EAW71262 EAW71263 O94887 AB018336 BAA34513 AK127510 AK300435 BAH13284 AL122052 CAB59185 AW014580 BC021301 AAH21301 BC036887 BQ028038 DB451463 HY312568 JF432117 ADZ15334 XM_005247050 XP_005247107 XM_011512233 XP_011510535 XM_011512234 XP_011510536 XM_011512235 XP_011510537 XM_011512236 XP_011510538 XM_011512237 XP_011510539 NM_001282983 NP_001269912 NM_001282984 NP_001269913 NM_014808 NP_055623
|
| Function |
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
|
| Top Pathways |
Adherens junction, Rap1 signaling pathway
|