Gene Symbol | FARP2 |
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Entrez Gene | 9855 |
Alt Symbol | FIR, FRG, PLEKHC3 |
Species | Human |
Gene Type | protein-coding |
Description | FERM, RhoGEF and pleckstrin domain protein 2 |
Other Description | FERM domain including RhoGEF|FERM, RhoGEF and pleckstrin domain-containing protein 2|FGD1-related Cdc42-GEF|PH domain-containing family C member 3|pleckstrin homology domain-containing family C member 3 |
Swissprots | F5GZ84 B7Z6J8 Q53QM5 Q8WU27 O94887 Q9UFE7 |
Accessions | AAY14682 EAW71262 EAW71263 O94887 AB018336 BAA34513 AK127510 AK300435 BAH13284 AL122052 CAB59185 AW014580 BC021301 AAH21301 BC036887 BQ028038 DB451463 HY312568 JF432117 ADZ15334 XM_005247050 XP_005247107 XM_011512233 XP_011510535 XM_011512234 XP_011510536 XM_011512235 XP_011510537 XM_011512236 XP_011510538 XM_011512237 XP_011510539 NM_001282983 NP_001269912 NM_001282984 NP_001269913 NM_014808 NP_055623 |
Function | Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
Top Pathways | Adherens junction, Rap1 signaling pathway |
FARP2 CRISPR/Cas9 KO Plasmid (h) - sc-411366 from Santa Cruz Biotechnology
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FARP2 HDR Plasmid (h) - sc-411366-HDR from Santa Cruz Biotechnology
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FARP2 Double Nickase Plasmid (h) - sc-411366-NIC from Santa Cruz Biotechnology
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FARP2 Double Nickase Plasmid (h2) - sc-411366-NIC-2 from Santa Cruz Biotechnology
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FARP2 CRISPR Activation Plasmid (h) - sc-411366-ACT from Santa Cruz Biotechnology
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FARP2 CRISPR Activation Plasmid (h2) - sc-411366-ACT-2 from Santa Cruz Biotechnology
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FARP2 Lentiviral Activation Particles (h) - sc-411366-LAC from Santa Cruz Biotechnology
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FARP2 Lentiviral Activation Particles (h2) - sc-411366-LAC-2 from Santa Cruz Biotechnology
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FARP2 siRNA (h) - sc-94823 from Santa Cruz Biotechnology
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FARP2 shRNA Plasmid (h) - sc-94823-SH from Santa Cruz Biotechnology
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FARP2 shRNA (h) Lentiviral Particles - sc-94823-V from Santa Cruz Biotechnology
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FARP2 RNAi - H00009855-R01 from Novus Biologicals
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MISSION® esiRNA - EHU001621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8483 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8483 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05745 from Sigma-Aldrich
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FARP2 siRNA (Human) - CRH6605 from Cohesion Biosciences
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FARP2 - MBS8203211 from MyBioSource
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shRNA set against Human FARP2 (NM_014808.2) - SHH292425 from Creative biogene
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FARP2 shRNA Plasmid (Human) - CHH6605 from Cohesion Biosciences
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FARP2 miRNA 3'UTR clone - MiUTR3H-14916 from Creative biogene
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