MAGEC2

Gene Symbol	MAGEC2
Entrez Gene	51438
Alt Symbol	CT10, HCA587, MAGEE1
Species	Human
Gene Type	protein-coding
Description	melanoma antigen family C2
Other Description	MAGE-C2 antigen|MAGE-E1 antigen|cancer/testis antigen 10|hepatocellular cancer antigen 587|hepatocellular carcinoma-associated antigen 587|melanoma antigen family C, 2|melanoma antigen, family E, 1, cancer/testis specific|melanoma-associated antigen C2
Swissprots	Q5JZ00 Q9P1M6 Q9P1M7 Q96D45 Q9UBF1
Accessions	AAF07211 AAF34817 AAK15073 EAW78014 EAW78015 EAW78016 Q9UBF1 AF116194 AAF34816 AF151378 AAF36533 AF196482 AAF07210 AK313591 BAG36358 BC005891 AAH05891 BC013318 AAH13318 BM548987 BP370466 CR457168 CAG33449 DQ892942 ABM83868 DQ896191 ABM87190 NM_016249 NP_057333
Function	Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Tissue Specificity	Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12920247}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAGEE1 protein fragment - ab162551 from Abcam Category Protein Source Wheat germ Species Human

MAGEC2 / CT10 Antibody Blocking Peptide - LS-E21925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Melanoma antigen family C2 Protein - H00051438-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAGEC2 Blocking Peptide - 33R-8333 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAGEC2 Blocking Peptide - abx063864 from Abbexa Category Peptide Species Human, Mouse, Rat

MAGE-C2 - H00051438-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MAGE-C2 - H00051438-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MAGEC2 fusion protein - ag0418 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MAGEC2 fusion protein - Ag17423 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MAGEC2 Blocking Peptide - CBP2670 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MAGEC2 Peptide - BS5956P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Melanoma-associated antigen C2(MAGEC2) - CSB-YP887003HU CSB-EP887003HU CSB-BP887003HU CSB-MP887003HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAGEC2 Protein - abx163140 from Abbexa Category Protein Species Human

MAGE-C2 (full length, N-term HIS tag) - TP760537 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human MAGEC2 protein, His-tagged - MAGEC2-152H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MAGEC2 protein, His-tagged - MAGEC2-191H from Creative Biomart Category Protein Source E. coli Species Human

Melanoma antigen family C2 Recombinant Protein Antigen - NBP2-34145PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MAGEE1-Antibody-N-term-Blocking-Peptide - BP6178a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAGEC2 Peptide, Human - M34GP09100H from Creative Peptides Category Peptide Source Synthetic. Species Human

Melanoma-associated antigen C2 (191-200) - ta-046 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen C2 (336-344) - ta-488 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen C2 (307-315) - ta-489 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen C2 (42-50) - ta-490 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen C2 (43-57) - ta-491 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen C2 (MAGEC2), Recombinant Protein - MBS1314002 from MyBioSource Category Protein Prices $1,140.00, $1,140.00, $1,370.00, $1,370.00, $1,815.00, $1,815.00, $2,280.00, $2,280.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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