| Gene Symbol | MAGEC2 |
|---|---|
| Entrez Gene | 51438 |
| Alt Symbol | CT10, HCA587, MAGEE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | melanoma antigen family C2 |
| Other Description | MAGE-C2 antigen|MAGE-E1 antigen|cancer/testis antigen 10|hepatocellular cancer antigen 587|hepatocellular carcinoma-associated antigen 587|melanoma antigen family C, 2|melanoma antigen, family E, 1, cancer/testis specific|melanoma-associated antigen C2 |
| Swissprots | Q5JZ00 Q9P1M6 Q9P1M7 Q96D45 Q9UBF1 |
| Accessions | AAF07211 AAF34817 AAK15073 EAW78014 EAW78015 EAW78016 Q9UBF1 AF116194 AAF34816 AF151378 AAF36533 AF196482 AAF07210 AK313591 BAG36358 BC005891 AAH05891 BC013318 AAH13318 BM548987 BP370466 CR457168 CAG33449 DQ892942 ABM83868 DQ896191 ABM87190 NM_016249 NP_057333 |
| Function | Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. |
| Tissue Specificity | Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12920247}. |
MAGE-C2 CRISPR/Cas9 KO Plasmid (h) - sc-405516 from Santa Cruz Biotechnology
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MAGE-C2 HDR Plasmid (h) - sc-405516-HDR from Santa Cruz Biotechnology
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MAGE-C2 Double Nickase Plasmid (h) - sc-405516-NIC from Santa Cruz Biotechnology
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MAGE-C2 Double Nickase Plasmid (h2) - sc-405516-NIC-2 from Santa Cruz Biotechnology
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MAGE-C2 CRISPR Activation Plasmid (h) - sc-405516-ACT from Santa Cruz Biotechnology
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MAGE-C2 CRISPR Activation Plasmid (h2) - sc-405516-ACT-2 from Santa Cruz Biotechnology
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MAGE-C2 Lentiviral Activation Particles (h) - sc-405516-LAC from Santa Cruz Biotechnology
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MAGE-C2 Lentiviral Activation Particles (h2) - sc-405516-LAC-2 from Santa Cruz Biotechnology
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MAGE-C2 siRNA (h) - sc-62580 from Santa Cruz Biotechnology
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MAGE-C2 shRNA Plasmid (h) - sc-62580-SH from Santa Cruz Biotechnology
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MAGE-C2 shRNA (h) Lentiviral Particles - sc-62580-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12930 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12930 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12188 from Sigma-Aldrich
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MAGEC2 siRNA (Human) - CRH9763 from Cohesion Biosciences
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MAGEC2 shRNA Plasmid (Human) - CHH9763 from Cohesion Biosciences
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MAGEC2 miRNA 3'UTR clone - MiUTR3H-02787 from Creative biogene
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