| Gene Symbol |
PTGES2
|
| Entrez Gene |
80142
|
| Alt Symbol |
C9orf15, GBF-1, GBF1, PGES2, mPGES-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin E synthase 2
|
| Other Description |
GATE-binding factor 1|gamma-interferon-activated transcriptional element-binding factor 1|mPGE synthase-2|membrane-associated prostaglandin E synthase 2|membrane-associated prostaglandin E synthase-2|microsomal prostaglandin E synthase-2|prostaglandin-H(2) E-isomerase
|
| Swissprots |
Q96GI0 Q5SYV6 Q9H7Z7 Q53EW9 Q96GL2
|
| Accessions |
EAW87741 EAW87742 EAW87743 EAW87744 EAW87745 EAW87746 Q9H7Z7 AK024100 BAB14826 AK057049 BAG51854 AK223520 BAD97240 AK301618 BAG63103 AL525982 AM392565 CAL37443 AW073370 BC009397 AAH09397 BC009456 AAH09456 BC011613 AAH11613 BE797008 BG481657 BG823488 BI761840 BI826720 BM739176 BQ889675 BX493085 DQ891904 ABM82830 DQ895090 ABM86016 XM_005252239 XP_005252296 XM_011519050 XP_011517352 XM_011519051 XP_011517353 NM_001256335 NP_001243264 NM_025072 NP_079348 NM_198938 NP_945176 NM_198939 NM_198940 NR_027812
|
| Function |
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). {ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:18198127}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000269|PubMed:12835322}.
|
| Tissue Specificity |
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer. {ECO:0000269|PubMed:11866447}.
|
| Top Pathways |
Arachidonic acid metabolism
|