PTGES2
| Gene Symbol | PTGES2 |
|---|---|
| Entrez Gene | 80142 |
| Alt Symbol | C9orf15, GBF-1, GBF1, PGES2, mPGES-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | prostaglandin E synthase 2 |
| Other Description | GATE-binding factor 1|gamma-interferon-activated transcriptional element-binding factor 1|mPGE synthase-2|membrane-associated prostaglandin E synthase 2|membrane-associated prostaglandin E synthase-2|microsomal prostaglandin E synthase-2|prostaglandin-H(2) E-isomerase |
| Swissprots | Q96GI0 Q5SYV6 Q9H7Z7 Q53EW9 Q96GL2 |
| Accessions | EAW87741 EAW87742 EAW87743 EAW87744 EAW87745 EAW87746 Q9H7Z7 AK024100 BAB14826 AK057049 BAG51854 AK223520 BAD97240 AK301618 BAG63103 AL525982 AM392565 CAL37443 AW073370 BC009397 AAH09397 BC009456 AAH09456 BC011613 AAH11613 BE797008 BG481657 BG823488 BI761840 BI826720 BM739176 BQ889675 BX493085 DQ891904 ABM82830 DQ895090 ABM86016 XM_005252239 XP_005252296 XM_011519050 XP_011517352 XM_011519051 XP_011517353 NM_001256335 NP_001243264 NM_025072 NP_079348 NM_198938 NP_945176 NM_198939 NM_198940 NR_027812 |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). {ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:18198127}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000269|PubMed:12835322}. |
| Tissue Specificity | Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer. {ECO:0000269|PubMed:11866447}. |
| Top Pathways | Arachidonic acid metabolism |
PGE synthase 2 CRISPR/Cas9 KO Plasmid (h) - sc-408285 from Santa Cruz Biotechnology
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PGE synthase 2 HDR Plasmid (h) - sc-408285-HDR from Santa Cruz Biotechnology
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PGE synthase 2 Double Nickase Plasmid (h) - sc-408285-NIC from Santa Cruz Biotechnology
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PGE synthase 2 Double Nickase Plasmid (h2) - sc-408285-NIC-2 from Santa Cruz Biotechnology
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PGE synthase 2 CRISPR Activation Plasmid (h) - sc-408285-ACT from Santa Cruz Biotechnology
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PGE synthase 2 CRISPR Activation Plasmid (h2) - sc-408285-ACT-2 from Santa Cruz Biotechnology
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PGE synthase 2 Lentiviral Activation Particles (h) - sc-408285-LAC from Santa Cruz Biotechnology
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PGE synthase 2 Lentiviral Activation Particles (h2) - sc-408285-LAC-2 from Santa Cruz Biotechnology
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PGE synthase 2 siRNA (h) - sc-92841 from Santa Cruz Biotechnology
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PGE synthase 2 shRNA Plasmid (h) - sc-92841-SH from Santa Cruz Biotechnology
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PGE synthase 2 shRNA (h) Lentiviral Particles - sc-92841-V from Santa Cruz Biotechnology
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Prostaglandin E Synthase 2/PTGES2 RNAi - H00080142-R02 from Novus Biologicals
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Prostaglandin E Synthase 2/PTGES2 RNAi - H00080142-R01 from Novus Biologicals
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Prostaglandin E Synthase 2/PTGES2 RNAi - H00080142-R03 from Novus Biologicals
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MISSION® esiRNA - EHU064301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17669 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17669 from Sigma-Aldrich
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PTGES2 siRNA (Human) - CRJ2767 from Cohesion Biosciences
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shRNA set against Human PTGES2 (NM_025072.6) - SHH386036 from Creative biogene
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PTGES2 shRNA Plasmid (Human) - CHJ2767 from Cohesion Biosciences
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PTGES2 miRNA 3'UTR clone - MiUTR3H-09797 from Creative biogene
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