| Gene Symbol | VPS25 |
|---|---|
| Entrez Gene | 84313 |
| Alt Symbol | DERP9, EAP20, FAP20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | vacuolar protein sorting 25 homolog (S. cerevisiae) |
| Other Description | ELL-associated protein of 20 kDa|ESCRT-II complex subunit VPS25|dermal papilla-derived protein 9|vacuolar protein-sorting-associated protein 25 |
| Swissprots | B2R581 Q9BRG1 |
| Accessions | EAW60879 EAW60880 Q9BRG1 AB014763 BAB87804 AK312092 BAG35028 BC006282 AAH06282 BU630023 HQ448303 ADQ32783 NM_032353 NP_115729 |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. {ECO:0000269|PubMed:18723511}. |
| Subcellular Location | Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. |
| Tissue Specificity | Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. {ECO:0000269|PubMed:16889659}. |
| Top Pathways | Endocytosis |