VPS25

Gene Symbol VPS25
Entrez Gene 84313
Alt Symbol DERP9, EAP20, FAP20
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 25 homolog (S. cerevisiae)
Other Description ELL-associated protein of 20 kDa|ESCRT-II complex subunit VPS25|dermal papilla-derived protein 9|vacuolar protein-sorting-associated protein 25
Swissprots B2R581 Q9BRG1
Accessions EAW60879 EAW60880 Q9BRG1 AB014763 BAB87804 AK312092 BAG35028 BC006282 AAH06282 BU630023 HQ448303 ADQ32783 NM_032353 NP_115729
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. {ECO:0000269|PubMed:18723511}.
Subcellular Location Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
Tissue Specificity Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. {ECO:0000269|PubMed:16889659}.
Top Pathways Endocytosis

VPS25 CRISPR/Cas9 KO Plasmid (h) - sc-404109 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 HDR Plasmid (h) - sc-404109-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 Double Nickase Plasmid (h) - sc-404109-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 Double Nickase Plasmid (h2) - sc-404109-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 CRISPR Activation Plasmid (h) - sc-404109-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 CRISPR Activation Plasmid (h2) - sc-404109-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 Lentiviral Activation Particles (h) - sc-404109-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 Lentiviral Activation Particles (h2) - sc-404109-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS25 siRNA (h) - sc-61794 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VPS25 shRNA Plasmid (h) - sc-61794-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VPS25 shRNA (h) Lentiviral Particles - sc-61794-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VPS25 RNAi - H00084313-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU013451 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22712 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22712 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04056 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04056

VPS25 siRNA (Human) - CRJ3435 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VPS25 - MBS8237284 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VPS25 (NM_032353.2) - SHH444868 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human VPS25(NM_032353.2) - SHL127416 from Creative biogene

Category siRNA
Species Reactivities Human

Human VPS25 siRNA - orb273936 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VPS25 shRNA Plasmid (Human) - CHJ3435 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VPS25 miRNA 3'UTR clone - MiUTR1H-11143 from Creative biogene

Species Reactivities Human
Search more