WTAP

Gene Symbol WTAP
Entrez Gene 9589
Alt Symbol Mum2
Species Human
Gene Type protein-coding
Description Wilms tumor 1 associated protein
Other Description PNAS-132|WT1-associated protein|Wilms' tumour 1-associating protein|female-lethal(2)D homolog|hFL(2)D|pre-mRNA-splicing regulator WTAP|putative pre-mRNA splicing regulator female-lethal(2D)|wilms tumor 1-associating protein
Swissprots Q9BYJ7 Q15007 Q5TCL9 Q9H4E2 Q96T28 Q5TCL8
Accessions EAW47622 EAW47623 EAW47624 EAW47625 EAW47626 EAW47627 EAW47628 Q15007 AA706250 AF277190 AAK07548 AF374416 AAK54764 AJ276706 CAC10188 AK127822 BAG54579 AK131393 AK290854 BAF83543 AL583911 CAC29495 BC000383 AAH00383 BC004432 AAH04432 BC028180 BC069192 AAH69192 BE906617 BG702882 BQ778248 BQ948913 BX387163 CN284477 CR627456 CAH10537 D14661 BAA03495 DA138013 DA561768 HQ447554 ADQ32040 XM_011536264 XP_011534566 NM_001270531 NP_001257460 NM_001270532 NP_001257461 NM_001270533 NP_001257462 NM_004906 NP_004897 NM_152857 NP_690596 NM_152858 NP_690597
Function Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}.
Subcellular Location Nucleus, nucleolus. Nucleus speckle.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:11001926}.

WTAP (D-7) - sc-374280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WTAP (D-7): sc-374280. Western blot analysis of WTAP expression in K-562 (A) and Jurkat (B) nuclear extracts.

WTAP (E-19) - sc-55439 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WTAP (E-19): sc-55439. Western blot analysis of WTAP expression in K-562 nuclear extract.

WTAP (G-20) - sc-55440 from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Goat
Clonality Polyclonal

WTAP (C-12) - sc-166931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WTAP (C-12): sc-166931. Western blot analysis of WTAP expression in Jurkat (A) and K-562 (B) nuclear extracts.

WTAP (C-20) - sc-55438 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WTAP (C-20): sc-55438. Western blot analysis of WTAP expression in K-562 (A) and Jurkat (B) nuclear extracts.

WTAP (H-306) - sc-67389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
WTAP (H-306): sc-67389. Western blot analysis of WTAP expression in K-562 nuclear extract.

WTAP (K-17) - sc-55441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WTAP antibody - ab118331 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-WTAP antibody (ab118331) at 5 µg/ml + Recombinant immunogen at 0.2 µgdeveloped using the ECL technique

Anti-WTAP antibody - ab14308 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-WTAP antibody (ab14308) at 1/2000 dilution + E.coli derived WTAP fusion protein.SecondaryHRP conjugated goat anti IgY at 1/1000 dilution

Anti-WTAP antibody - ab64958 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-WTAP antibody (ab64958) at 1/500 dilutionLane 1 : HUVEC extractLane 2 : HUVEC extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-WTAP antibody - ab130688 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-WTAP antibody (ab130688) at 1/100 dilution + Jurkat cell line lysates at 35 µgdeveloped using the ECL technique

Anti-WTAP antibody - ab99397 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of WTAP in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab99397 at 3 µg/mg lysate for IP. An anti-WTAP antibody which recognizes a downstream epitope was used at 1 µg/ml for subsequent Western blot detection. Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-WTAP Antibody (aa1-151) - LS-C90500 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, APC) - LS-C273644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, AP) - LS-C273643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, Biotin) - LS-C273645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, FITC) - LS-C273646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, Azide-free, HRP) - LS-C273647 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa272-301, PE) - LS-C273649 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa250-300) - LS-C288227 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa271-301) - LS-C326378 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WTAP Antibody (aa346-396) - LS-C288231 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human WTAP by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-WTAP used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-WTAP Antibody (aa321-370) - LS-C119050 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HUVEC cells, using WTAP Antibody. The lane on the right is treated with the synthesized peptide.

Anti-WTAP Antibody (aa272-301) - LS-C160644 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WTAP Antibody western blot of Jurkat cell line lysates (35 ug/lane). The WTAP antibody detected the WTAP protein (arrow).

Anti-WTAP Antibody (aa2-106, clone 12G6) - LS-C340479 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 12G6
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-WTAP mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).
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