| Gene Symbol |
CDKAL1
|
| Entrez Gene |
54901
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDK5 regulatory subunit associated protein 1-like 1
|
| Other Description |
tRNA-t(6)A37 methylthiotransferase|threonylcarbamoyladenosine tRNA methylthiotransferase
|
| Swissprots |
Q6P385 Q9NXB3 A8K6S0 Q5VV42 Q6ZR27
|
| Accessions |
CAK32475 EAW55425 EAW55426 EAW55427 Q5VV42 AK000349 BAA91102 AK024151 AK074342 AK128546 BAC87494 AK291735 BAF84424 AK309457 AK310219 BC064145 AAH64145 BC121020 AAI21021 BC121021 AAI21022 XM_006715128 XP_006715191 XM_011514718 XP_011513020 XM_011514719 XP_011513021 XR_926265 XR_926266 XR_926267 NM_017774 NP_060244
|
| Function |
Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000269|PubMed:20584901}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000269|PubMed:23048041}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum.
|
| Tissue Specificity |
Expressed in pancreatic islets. {ECO:0000269|PubMed:23048041}.
|
![Western Blot: CDKAL1 Overexpression Lysate (Adult Normal) [NBP2-06920] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDKAL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/16467_CDKAL1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06920-img0001.jpg)