Gene Symbol | CDKAL1 |
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Entrez Gene | 54901 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | CDK5 regulatory subunit associated protein 1-like 1 |
Other Description | tRNA-t(6)A37 methylthiotransferase|threonylcarbamoyladenosine tRNA methylthiotransferase |
Swissprots | Q6P385 Q9NXB3 A8K6S0 Q5VV42 Q6ZR27 |
Accessions | CAK32475 EAW55425 EAW55426 EAW55427 Q5VV42 AK000349 BAA91102 AK024151 AK074342 AK128546 BAC87494 AK291735 BAF84424 AK309457 AK310219 BC064145 AAH64145 BC121020 AAI21021 BC121021 AAI21022 XM_006715128 XP_006715191 XM_011514718 XP_011513020 XM_011514719 XP_011513021 XR_926265 XR_926266 XR_926267 NM_017774 NP_060244 |
Function | Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000269|PubMed:20584901}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000269|PubMed:23048041}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. |
Tissue Specificity | Expressed in pancreatic islets. {ECO:0000269|PubMed:23048041}. |
CDKAL1 CRISPR/Cas9 KO Plasmid (h) - sc-407620 from Santa Cruz Biotechnology
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CDKAL1 HDR Plasmid (h) - sc-407620-HDR from Santa Cruz Biotechnology
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CDKAL1 Double Nickase Plasmid (h) - sc-407620-NIC from Santa Cruz Biotechnology
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CDKAL1 Double Nickase Plasmid (h2) - sc-407620-NIC-2 from Santa Cruz Biotechnology
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CDKAL1 CRISPR Activation Plasmid (h) - sc-407620-ACT from Santa Cruz Biotechnology
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CDKAL1 CRISPR Activation Plasmid (h2) - sc-407620-ACT-2 from Santa Cruz Biotechnology
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CDKAL1 Lentiviral Activation Particles (h) - sc-407620-LAC from Santa Cruz Biotechnology
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CDKAL1 Lentiviral Activation Particles (h2) - sc-407620-LAC-2 from Santa Cruz Biotechnology
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CDKAL1 siRNA (h) - sc-95524 from Santa Cruz Biotechnology
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CDKAL1 shRNA Plasmid (h) - sc-95524-SH from Santa Cruz Biotechnology
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CDKAL1 shRNA (h) Lentiviral Particles - sc-95524-V from Santa Cruz Biotechnology
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CDKAL1 RNAi - H00054901-R01 from Novus Biologicals
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MISSION® esiRNA - EHU020201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5857 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5857 from Sigma-Aldrich
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CDKAL1 siRNA (Human) - CRJ0310 from Cohesion Biosciences
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CDKAL1 - MBS8228366 from MyBioSource
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shRNA set against Human CDKAL1 (NM_017774.3) - SHH260741 from Creative biogene
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CDKAL1 shRNA Plasmid (Human) - CHJ0310 from Cohesion Biosciences
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CDKAL1 miRNA 3'UTR clone - MiUTR3H-11754 from Creative biogene
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