ASCL1

Gene Symbol ASCL1
Entrez Gene 429
Alt Symbol ASH1, HASH1, MASH1, bHLHa46
Species Human
Gene Type protein-coding
Description achaete-scute family bHLH transcription factor 1
Other Description ASH-1|achaete scute protein|achaete-scute complex homolog 1|achaete-scute complex-like 1|achaete-scute homolog 1|class A basic helix-loop-helix protein 46
Swissprots Q9BQ30 A8K3C4 P50553
Accessions EAW97703 P50553 AK290539 BAF83228 AK314114 AW071836 BC001638 BC002341 AAH02341 BC003134 AAH03134 BC004425 AAH04425 BC031299 AAH31299 CF454566 DA005289 DQ894571 ABM85497 EU176303 ABW03754 L08424 AAA58376 NM_004316 NP_004307
Function Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000305}.

Human ASCL1 ORF Clone(NM_004316.3) - CDCL154602 from Creative Biomart

Species Human
Accession NM_004316.3
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