Gene Symbol | ASCL1 |
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Entrez Gene | 429 |
Alt Symbol | ASH1, HASH1, MASH1, bHLHa46 |
Species | Human |
Gene Type | protein-coding |
Description | achaete-scute family bHLH transcription factor 1 |
Other Description | ASH-1|achaete scute protein|achaete-scute complex homolog 1|achaete-scute complex-like 1|achaete-scute homolog 1|class A basic helix-loop-helix protein 46 |
Swissprots | Q9BQ30 A8K3C4 P50553 |
Accessions | EAW97703 P50553 AK290539 BAF83228 AK314114 AW071836 BC001638 BC002341 AAH02341 BC003134 AAH03134 BC004425 AAH04425 BC031299 AAH31299 CF454566 DA005289 DQ894571 ABM85497 EU176303 ABW03754 L08424 AAA58376 NM_004316 NP_004307 |
Function | Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
ASCL1 CRISPR/Cas9 KO Plasmid (h) - sc-402039 from Santa Cruz Biotechnology
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ASCL1 HDR Plasmid (h) - sc-402039-HDR from Santa Cruz Biotechnology
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ASCL1 Double Nickase Plasmid (h) - sc-402039-NIC from Santa Cruz Biotechnology
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ASCL1 Double Nickase Plasmid (h2) - sc-402039-NIC-2 from Santa Cruz Biotechnology
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ASCL1 CRISPR Activation Plasmid (h) - sc-402039-ACT from Santa Cruz Biotechnology
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ASCL1 CRISPR Activation Plasmid (h2) - sc-402039-ACT-2 from Santa Cruz Biotechnology
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ASCL1 Lentiviral Activation Particles (h) - sc-402039-LAC from Santa Cruz Biotechnology
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ASCL1 Lentiviral Activation Particles (h2) - sc-402039-LAC-2 from Santa Cruz Biotechnology
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ASCL1 siRNA (h) - sc-37692 from Santa Cruz Biotechnology
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ASCL1 shRNA Plasmid (h) - sc-37692-SH from Santa Cruz Biotechnology
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ASCL1 shRNA (h) Lentiviral Particles - sc-37692-V from Santa Cruz Biotechnology
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ASCL1/Mash1 RNAi - H00000429-R01 from Novus Biologicals
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MISSION® esiRNA - EHU000491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3588 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3588 from Sigma-Aldrich
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ASCL1 siRNA (Human) - CRH0309 from Cohesion Biosciences
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ASCL1 - MBS8222469 from MyBioSource
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ASCL1 CRISPR/Cas9 KO Plasmid (h2) - sc-402039-KO-2 from Santa Cruz Biotechnology
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ASCL1 HDR Plasmid (h2) - sc-402039-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ASCL1 (NM_004316.3) - SHH241382 from Creative biogene
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ASCL1 shRNA Plasmid (Human) - CHH0309 from Cohesion Biosciences
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ASCL1 miRNA 3'UTR clone - MiUTR3H-00013 from Creative biogene
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