| Gene Symbol |
HSD3B7
|
| Entrez Gene |
80270
|
| Alt Symbol |
CBAS1, PFIC4, SDR11E3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
|
| Other Description |
3 beta-hydroxy-delta 5-C27-steroid oxidoreductase|3 beta-hydroxysteroid dehydrogenase type 7|3 beta-hydroxysteroid dehydrogenase type VII|3-beta-HSD VII|3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase|C(27)-3BETA-HSD|c(27) 3-beta-HSD|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase|short chain dehydrogenase/reductase family 11E, member 3
|
| Swissprots |
Q9BSN9 Q9H2F3 Q96M28
|
| Accessions |
EAW52183 Q9H2F3 AF277719 AAG37824 AK057436 BAB71486 AK290950 BAF83639 AK292068 BAF84757 BC004929 AAH04929 BM744211 CA413388 DB336146 EU176407 ABW03858 EU176408 ABW03859 XM_005255601 XP_005255658 XM_011545960 XP_011544262 XM_011545961 XP_011544263 XM_011545962 XP_011544264 NM_001142777 NP_001136249 NM_001142778 NP_001136250 NM_025193 NP_079469
|
| Function |
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Top Pathways |
Primary bile acid biosynthesis
|