| Gene Symbol |
ELOVL7
|
| Entrez Gene |
79993
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELOVL fatty acid elongase 7
|
| Other Description |
3-keto acyl-CoA synthase ELOVL7|ELOVL FA elongase 7|ELOVL family member 7, elongation of long chain fatty acids|elongation of very long chain fatty acids protein 7|very-long-chain 3-oxoacyl-CoA synthase 7
|
| Swissprots |
Q9NT66 A1L3X0 Q9H5D0 Q589T3
|
| Accessions |
A1L3X0 EAW55001 EAW55002 AB181393 BAD93238 AI769834 AK027216 BAB15697 AL137506 CAB70777 BC094792 BC130310 AAI30311 BC130312 AAI30313 BC144257 DA247166 HQ258375 ADR83129 XM_005248606 XP_005248663 XM_005248607 XP_005248664 XM_006714695 XP_006714758 XM_011543651 XP_011541953 NM_001104558 NP_001098028 NM_001297617 NP_001284546 NM_001297618 NP_001284547 NM_024930 NP_079206
|
| Function |
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:19826053, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Expressed in most tissues except heart and skeletal muscle. {ECO:0000269|PubMed:20937905}.
|
| Top Pathways |
Fatty acid elongation
|