NUMBL

Gene Symbol	NUMBL
Entrez Gene	9253
Alt Symbol	CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Species	Human
Gene Type	protein-coding
Description	numb homolog (Drosophila)-like
Other Description	numb homolog-like|numb-like protein|numb-related protein
Swissprots	Q7Z4J9 Q9Y6R0
Accessions	EAW56986 Q9Y6R0 AF015041 AAD01549 AI374943 AK289398 BAF82087 AK299484 BAH13046 BC001794 BC016160 BC144583 BC167835 AAI67835 BI552675 BT009807 AAP88809 CF138383 HY111715 U80758 AAB91449 XM_011527489 XP_011525791 XM_011527490 XP_011525792 XR_935869 NM_001289979 NP_001276908 NM_001289980 NP_001276909 NM_004756 NP_004747
Function	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NumbL (C-4) - sc-390590 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NumbL (H-5) - sc-390799 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NumbL (H-80) - sc-135071 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NumbL (N-17) - sc-54469 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NumbL (T-15) - sc-54525 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NUMBL antibody - ab37500 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUMBL antibody - ab5641 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-NUMBL antibody - ab116296 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUMBL antibody - N-terminal - ab80119 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUMBL antibody - N-terminal - ab189947 from Abcam Prices $407.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa200-250) - LS-C73853 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa545-595) - LS-C73854 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (Internal) - LS-C186566 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, AP) - LS-C216126 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, APC) - LS-C216127 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, Biotin) - LS-C216128 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, FITC) - LS-C216129 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, Azide-free, HRP) - LS-C216130 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600, PE) - LS-C216132 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa200-250) - LS-C288505 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa545-595) - LS-C288527 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa571-600) - LS-C323484 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody - LS-C192948 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody (aa572-600) - LS-C163065 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NUMBLIKE / NUMBL Antibody - LS-C331930 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Search more