NUMBL

Gene Symbol NUMBL
Entrez Gene 9253
Alt Symbol CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Species Human
Gene Type protein-coding
Description numb homolog (Drosophila)-like
Other Description numb homolog-like|numb-like protein|numb-related protein
Swissprots Q7Z4J9 Q9Y6R0
Accessions EAW56986 Q9Y6R0 AF015041 AAD01549 AI374943 AK289398 BAF82087 AK299484 BAH13046 BC001794 BC016160 BC144583 BC167835 AAI67835 BI552675 BT009807 AAP88809 CF138383 HY111715 U80758 AAB91449 XM_011527489 XP_011525791 XM_011527490 XP_011525792 XR_935869 NM_001289979 NP_001276908 NM_001289980 NP_001276909 NM_004756 NP_004747
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Top Pathways Notch signaling pathway

NumbL CRISPR/Cas9 KO Plasmid (h) - sc-408169 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL HDR Plasmid (h) - sc-408169-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL Double Nickase Plasmid (h) - sc-408169-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL Double Nickase Plasmid (h2) - sc-408169-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL CRISPR Activation Plasmid (h) - sc-408169-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL CRISPR Activation Plasmid (h2) - sc-408169-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL Lentiviral Activation Particles (h) - sc-408169-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL Lentiviral Activation Particles (h2) - sc-408169-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NumbL siRNA (h) - sc-62707 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NumbL shRNA Plasmid (h) - sc-62707-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NumbL shRNA (h) Lentiviral Particles - sc-62707-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU014731 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15616 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15616 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09934 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09934

NUMBL siRNA (Human) - CRH6126 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NUMBL (NM_004756.3) - SHH356328 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NUMBL(NM_004756.3) - SHR026490 from Creative biogene

Category siRNA
Species Reactivities Human

NUMBL shRNA Plasmid (Human) - CHH6126 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NUMBL miRNA 3'UTR clone - MiUTR1H-06981 from Creative biogene

Species Reactivities Human
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