NUMBL

Gene Symbol	NUMBL
Entrez Gene	9253
Alt Symbol	CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Species	Human
Gene Type	protein-coding
Description	numb homolog (Drosophila)-like
Other Description	numb homolog-like|numb-like protein|numb-related protein
Swissprots	Q7Z4J9 Q9Y6R0
Accessions	EAW56986 Q9Y6R0 AF015041 AAD01549 AI374943 AK289398 BAF82087 AK299484 BAH13046 BC001794 BC016160 BC144583 BC167835 AAI67835 BI552675 BT009807 AAP88809 CF138383 HY111715 U80758 AAB91449 XM_011527489 XP_011525791 XM_011527490 XP_011525792 XR_935869 NM_001289979 NP_001276908 NM_001289980 NP_001276909 NM_004756 NP_004747
Function	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NUMBL peptide - ab37499 from Abcam Category Peptide

Human NUMBL peptide - ab23104 from Abcam Category Peptide Species Human

NUMBLIKE / NUMBL Antibody Blocking Peptide - LS-E2954 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUMBLIKE / NUMBL Antibody Blocking Peptide - LS-E27897 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NUMBL-Antibody-Center-Blocking-peptide - BP12068c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NUMBL-Antibody-C-term-Blocking-peptide - BP14081b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NUMBL blocking peptide - GTX25641-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

NUMBL Peptide - AC21-2801-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NUMBL fusion protein - Ag17935 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NUMBL fusion protein - Ag18177 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NUMBLIKE fusion protein - Ag0156 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NUMBLIKE fusion protein - Ag16771 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human NUMBL, GST-tagged - NUMBL-1411H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NUMBL - NUMBL-673H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human NUMBL - NUMBL-1410H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Numb-like protein(NUMBL) - CSB-YP897595HU CSB-EP897595HU CSB-BP897595HU CSB-MP897595HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Numb-like protein / NUMBL - TP316869 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NUMBL, Peptide - MBS428304 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

NUMBL Recombinant Protein Antigen - NBP2-34112PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NUMBL Recombinant Protein Antigen - NBP2-34104PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NUMBL-Antibody-N-term-Blocking-peptide - BP2774a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NUMBL Peptide, Human - M34GP10729H from Creative Peptides Category Peptide Source Synthetic. Species Human

Numb-like protein (NUMBL), Recombinant Protein - MBS1383033 from MyBioSource Category Protein Prices $1,400.00, $1,400.00, $1,630.00, $1,630.00, $2,365.00, $2,365.00, $2,810.00, $2,810.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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