| Gene Symbol |
NUMBL
|
| Entrez Gene |
9253
|
| Alt Symbol |
CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
numb homolog (Drosophila)-like
|
| Other Description |
numb homolog-like|numb-like protein|numb-related protein
|
| Swissprots |
Q7Z4J9 Q9Y6R0
|
| Accessions |
EAW56986 Q9Y6R0 AF015041 AAD01549 AI374943 AK289398 BAF82087 AK299484 BAH13046 BC001794 BC016160 BC144583 BC167835 AAI67835 BI552675 BT009807 AAP88809 CF138383 HY111715 U80758 AAB91449 XM_011527489 XP_011525791 XM_011527490 XP_011525792 XR_935869 NM_001289979 NP_001276908 NM_001289980 NP_001276909 NM_004756 NP_004747
|
| Function |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
|
| Top Pathways |
Notch signaling pathway
|