Gene Symbol | SLCO1A2 |
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Entrez Gene | 6579 |
Alt Symbol | OATP, OATP-A, OATP1A2, SLC21A3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier organic anion transporter family, member 1A2 |
Other Description | OATP-1|organic anion transporting polypeptide A|organic anion-transporting polypeptide 1|sodium-independent organic anion transporter|solute carrier family 21 (organic anion transporter), member 3|solute carrier family 21 member 3|solute carrier organic anion transporter family member 1A2 |
Swissprots | Q9UGP7 Q9UL38 P46721 |
Accessions | CAB64372 CAB97006 EAW96422 EAW96423 EAW96424 EAW96425 P46721 AF085224 AAD52694 AF279784 AAG30037 AK296044 BAG58808 AK316249 BAH14620 BC042452 AAH42452 BC144256 BX093727 DA184882 DA216595 DA220201 DA322842 DA412674 U21943 AAA87732 XM_005253474 XP_005253531 XM_005253477 XP_005253534 XM_011520818 XP_011519120 XM_011520819 XP_011519121 XM_011520820 XP_011519122 XM_011520821 XP_011519123 NM_021094 NP_066580 NM_134431 NP_602307 NM_005075 |
Function | Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. {ECO:0000250, ECO:0000269|PubMed:17301733}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Bile secretion |
OATP-A CRISPR/Cas9 KO Plasmid (h) - sc-403995 from Santa Cruz Biotechnology
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OATP-A HDR Plasmid (h) - sc-403995-HDR from Santa Cruz Biotechnology
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OATP-A Double Nickase Plasmid (h) - sc-403995-NIC from Santa Cruz Biotechnology
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OATP-A Double Nickase Plasmid (h2) - sc-403995-NIC-2 from Santa Cruz Biotechnology
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OATP-A CRISPR Activation Plasmid (h) - sc-403995-ACT from Santa Cruz Biotechnology
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OATP-A CRISPR Activation Plasmid (h2) - sc-403995-ACT-2 from Santa Cruz Biotechnology
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OATP-A Lentiviral Activation Particles (h) - sc-403995-LAC from Santa Cruz Biotechnology
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OATP-A Lentiviral Activation Particles (h2) - sc-403995-LAC-2 from Santa Cruz Biotechnology
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OATP-A siRNA (h) - sc-42548 from Santa Cruz Biotechnology
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OATP-A shRNA Plasmid (h) - sc-42548-SH from Santa Cruz Biotechnology
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OATP-A shRNA (h) Lentiviral Particles - sc-42548-V from Santa Cruz Biotechnology
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SLCO1A2 RNAi - H00006579-R02 from Novus Biologicals
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SLCO1A2 RNAi - H00006579-R03 from Novus Biologicals
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MISSION® esiRNA - EHU065911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19708 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19708 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10963 from Sigma-Aldrich
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SLCO1A2 siRNA (Human) - CRH4467 from Cohesion Biosciences
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SLCO1A2 RNAi - H00006579-R01 from Novus Biologicals
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SLCO1A2 - MBS8223555 from MyBioSource
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shRNA set against Human SLCO1A2 (NM_021094.3) - SHH412416 from Creative biogene
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Human SLCO1A2 siRNA - orb264969 from Biorbyt
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SLCO1A2 shRNA Plasmid (Human) - CHH4467 from Cohesion Biosciences
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SLCO1A2 miRNA 3'UTR clone - MiUTR4H-TG08283 from Creative biogene
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