SNRPD1

Gene Symbol SNRPD1
Entrez Gene 6632
Alt Symbol HsT2456, SMD1, SNRPD, Sm-D1
Species Human
Gene Type protein-coding
Description small nuclear ribonucleoprotein D1 polypeptide 16kDa
Other Description Sm-D autoantigen|small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene|small nuclear ribonucleoprotein Sm D1|snRNP core protein D1
Swissprots B5BTZ1 P62314
Accessions AAA85339 EAX01130 P62314 AB451227 BAG70041 AB451350 BAG70164 AJ577268 CAE11897 BC001721 AAH01721 BC072427 AAH72427 BU565530 CN354758 CR542239 CAG47035 HY043971 J03798 AAA36620 NM_001291916 NP_001278845 NM_006938 NP_008869
Function Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Top Pathways Systemic lupus erythematosus, Spliceosome

Sm D1 (A-9) - sc-166650 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sm D1 (A-9): sc-166650. Western blot analysis of Sm D1 expression in K-562 whole cell lysate (A) and HeLa (B) and Ramos (C) nuclear extracts.

Sm D1 (C-15) - sc-20822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sm D1 (C-15): sc-20822. Western blot analysis of Sm D1 expression in BJAB (A), Jurkat (B) and K-562 (C) nuclear extracts.

Sm D1 (H-100) - sc-366191 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Sm D1 (H-100): sc-366191. Western blot analysis of Sm D1 expression in Jurkat (A), K-562 (B), BJAB (C) and MCF7 (D) nuclear extracts.

Anti-SNRPD1 antibody - ab79975 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SNRPD1 antibody (ab79975) at 1/50 dilution + HL60 cell line lysates at 35 µg

Anti-SNRPD1 antibody - ab79977 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SNRPD1 antibody (ab79977) at 1/50 dilution + HL60 cell line lysates at 35 µg

Anti-SNRPD1 antibody [3032C3a] - ab59774 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3032C3a
Anti-SNRPD1 antibody [3032C3a] (ab59774) + immunizing peptide

Anti-SNRPD1 / SMD1 Antibody (clone 3032C3a) - LS-C184595 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3032C3a

Anti-SNRPD1 / SMD1 Antibody - LS-C75897 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SNRPD1 / SMD1 Antibody (N-Terminus) - LS-C145692 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SNRPD1 antibody LS-C145692 Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml.

Anti-SNRPD1 / SMD1 Antibody (clone 3032C3a) - LS-C342856 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3032C3a
Western blot analysis of immunized recombinant protein, using anti-SNRPD1 monoclonal antibody.

Anti-SNRPD1 / SMD1 Antibody (aa1-119) - LS-C314704 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SNRPD1 / SMD1.

Anti-SNRPD1 / SMD1 Antibody (aa21-70) - LS-C30326 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
SNRPD1 antibody LS-C30326 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SNRPD1 / SMD1 Antibody - LS-C346290 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of MCF7 cell using SNRPD1 antibody.

Anti-SNRPD1 / SMD1 Antibody (aa69-98) - LS-C97333 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human tonsil tissue reacted with SNRPD1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SNRPD1 / SMD1 Antibody (aa46-78) - LS-C97334 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SNRPD1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

SNRPD1 Antibody - NBP2-36427 from Novus Biologicals

Prices $499.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Hepatitis C Virus Core Antigen Antibody - NB100-93581 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ANTI-SNRPD1(C-TERMINAL) antibody produced in rabbit - SAB1307174 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SNRPD1 (C-term): <B>Cat. No. SAB1307174</B>: Western blot analysis of SNRPD1 (arrow) using Rabbit polyclonal SNRPD1 (Center) . 293 cell lysates (2 μg).<BR/><B>Lanes:</B><BR/>1. Nontransfected with the SNRPD1 gene<BR/>2. Transiently transfected with the SNRPD1 gene

Anti-SNRPD1 antibody produced in rabbit - HPA040516 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SNRPD1: <B>Cat. No. HPA040516</B>: Immunohistochemical staining of human kidney shows strong nuclear positivity in cells of tubules.

ANTI-SNRPD1 (CENTER) antibody produced in rabbit - SAB1307175 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SNRPD1 (Center): <B>Cat. No. SAB1307175</B>: Western blot analysis of Anti-SNRPD1 Antibody (Center) in HL60 cell line lysates (35 μg/lane).

snRNP B'B/D1 Antibody (OAMA01156) - OAMA01156 from Aviva Systems Biology

Prices $1,080.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone ANA126

SNRPD1 antibody - N-terminal region (ARP40693_P050) - ARP40693_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SNRPD1 Antibody - C-terminal region (OAAB01573) - OAAB01573 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SNRPD1 Antibody - middle region (OAAB01574) - OAAB01574 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SNRPD1-Antibody-Center - AP2842c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SNRPD1 Antibody (Center) (Cat.#AP2842c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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