| Gene Symbol | SNRPD1 |
|---|---|
| Entrez Gene | 6632 |
| Alt Symbol | HsT2456, SMD1, SNRPD, Sm-D1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | small nuclear ribonucleoprotein D1 polypeptide 16kDa |
| Other Description | Sm-D autoantigen|small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene|small nuclear ribonucleoprotein Sm D1|snRNP core protein D1 |
| Swissprots | B5BTZ1 P62314 |
| Accessions | AAA85339 EAX01130 P62314 AB451227 BAG70041 AB451350 BAG70164 AJ577268 CAE11897 BC001721 AAH01721 BC072427 AAH72427 BU565530 CN354758 CR542239 CAG47035 HY043971 J03798 AAA36620 NM_001291916 NP_001278845 NM_006938 NP_008869 |
| Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
| Top Pathways | Systemic lupus erythematosus, Spliceosome |
Sm D1 CRISPR/Cas9 KO Plasmid (h) - sc-418362 from Santa Cruz Biotechnology
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Sm D1 HDR Plasmid (h) - sc-418362-HDR from Santa Cruz Biotechnology
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Sm D1 Double Nickase Plasmid (h) - sc-418362-NIC from Santa Cruz Biotechnology
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Sm D1 Double Nickase Plasmid (h2) - sc-418362-NIC-2 from Santa Cruz Biotechnology
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Sm D1 CRISPR Activation Plasmid (h) - sc-418362-ACT from Santa Cruz Biotechnology
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Sm D1 CRISPR Activation Plasmid (h2) - sc-418362-ACT-2 from Santa Cruz Biotechnology
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Sm D1 Lentiviral Activation Particles (h) - sc-418362-LAC from Santa Cruz Biotechnology
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Sm D1 Lentiviral Activation Particles (h2) - sc-418362-LAC-2 from Santa Cruz Biotechnology
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Sm D1 siRNA (h) - sc-38325 from Santa Cruz Biotechnology
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Sm D1 shRNA Plasmid (h) - sc-38325-SH from Santa Cruz Biotechnology
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Sm D1 shRNA (h) Lentiviral Particles - sc-38325-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20270 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20270 from Sigma-Aldrich
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SNRPD1 siRNA (Human) - CRH4514 from Cohesion Biosciences
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SNRPD1 - MBS8215290 from MyBioSource
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shRNA set against Human SNRPD1 (NM_006938.2) - SHH414364 from Creative biogene
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shRNA set against Human SNRPD1(NM_006938.2) - SHL022112 from Creative biogene
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Human SNRPD1 siRNA - orb265016 from Biorbyt
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SNRPD1 shRNA Plasmid (Human) - CHH4514 from Cohesion Biosciences
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SNRPD1 miRNA 3'UTR clone - MiUTR1H-09699 from Creative biogene
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