| Gene Symbol |
SNRPD1
|
| Entrez Gene |
6632
|
| Alt Symbol |
HsT2456, SMD1, SNRPD, Sm-D1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein D1 polypeptide 16kDa
|
| Other Description |
Sm-D autoantigen|small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene|small nuclear ribonucleoprotein Sm D1|snRNP core protein D1
|
| Swissprots |
B5BTZ1 P62314
|
| Accessions |
AAA85339 EAX01130 P62314 AB451227 BAG70041 AB451350 BAG70164 AJ577268 CAE11897 BC001721 AAH01721 BC072427 AAH72427 BU565530 CN354758 CR542239 CAG47035 HY043971 J03798 AAA36620 NM_001291916 NP_001278845 NM_006938 NP_008869
|
| Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
|
| Top Pathways |
Systemic lupus erythematosus, Spliceosome
|