Gene Symbol | SNRPD1 |
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Entrez Gene | 6632 |
Alt Symbol | HsT2456, SMD1, SNRPD, Sm-D1 |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein D1 polypeptide 16kDa |
Other Description | Sm-D autoantigen|small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene|small nuclear ribonucleoprotein Sm D1|snRNP core protein D1 |
Swissprots | B5BTZ1 P62314 |
Accessions | AAA85339 EAX01130 P62314 AB451227 BAG70041 AB451350 BAG70164 AJ577268 CAE11897 BC001721 AAH01721 BC072427 AAH72427 BU565530 CN354758 CR542239 CAG47035 HY043971 J03798 AAA36620 NM_001291916 NP_001278845 NM_006938 NP_008869 |
Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
Top Pathways | Systemic lupus erythematosus, Spliceosome |
SNRPD1-Antibody-Center-Blocking-Peptide - BP2842c from Abgent, a WuXi AppTec company
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SNRPD1-Antibody-C-term-Blocking-Peptide - BP2842b from Abgent, a WuXi AppTec company
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Sm/RNP Antigen Protein (OPMA04153) - OPMA04153 from Aviva Systems Biology
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Sm/RNP Antigen Protein (OPMA04228) - OPMA04228 from Aviva Systems Biology
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Human SNRPD protein - orb169328 from Biorbyt
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Bovine SNRPD protein - orb169569 from Biorbyt
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SNRPD1 fusion protein - ag16331 from Proteintech Group
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SNRPD1 fusion protein - ag0364 from Proteintech Group
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Recombinant Human SNRPD protein - BP002064-PRO-997 from Syd Labs
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Recombinant Human SNRPD1 protein - BP002065-PRO-994 from Syd Labs
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Sm/RNP Antigen - GWB-CDBE95 from Genway Biotech
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Sm/RNP Antigen - GWB-CA4A65 from Genway Biotech
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Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) - RPB128Hu01 from Uscn Life Science Inc.
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Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1) - RPB128Hu01 from Cloud-clone
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Recombinant Human Small nuclear ribonucleoprotein Sm D1(SNRPD1) - CSB-YP022332HU CSB-EP022332HU CSB-BP022332HU CSB-MP022332HU from Cusabio
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SmD1 (83-119) - M07050 from Creative Peptides
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Smd1 - AF3175 from Creative Peptides
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Small nuclear ribonucleoprotein Sm D1 (11-19) - ta-236 from Creative Peptides
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SNRPD1 Recombinant Protein (OPCD07088) - OPCD07088 from Aviva Systems Biology
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Small Nuclear Ribonucleoprotein, Recombinant Protein - MBS145171 from MyBioSource
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Small nuclear ribonucleoprotein Sm D1 (SNRPD1), Recombinant Protein - MBS718933 from MyBioSource
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