| Gene Symbol |
SPRED2
|
| Entrez Gene |
200734
|
| Alt Symbol |
Spred-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sprouty-related, EVH1 domain containing 2
|
| Other Description |
sprouty protein with EVH-1 domain 2, related sequence|sprouty-related, EVH1 domain-containing protein 2
|
| Swissprots |
D6W5F7 A1L3V4 Q2NKX6 B7Z5K7 Q7Z698 E9PEP0
|
| Accessions |
EAW99904 EAW99905 EAW99906 Q7Z698 AF052178 AK025550 AK056479 BAG51727 AK299079 BAH12943 AK307714 AY299090 AAP59415 BC029300 BC111495 AAI11496 BC130292 AAI30293 BC136334 AAI36335 DA102390 DC335282 HQ258249 ADR83003 XM_005264200 XP_005264257 XM_005264201 XP_005264258 XM_005264202 XP_005264259 XM_006711966 XP_006712029 NM_001128210 NP_001121682 NM_181784 NP_861449
|
| Function |
Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.
|
| Subcellular Location |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.
|
| Tissue Specificity |
Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269|PubMed:15580519}.
|
| Top Pathways |
Jak-STAT signaling pathway
|
![Western Blot: SPRED2 Overexpression Lysate (Adult Normal) [NBP2-04888] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPRED2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4154_SPRED2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04888-img0001.jpg)