Gene Symbol | SPRED2 |
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Entrez Gene | 200734 |
Alt Symbol | Spred-2 |
Species | Human |
Gene Type | protein-coding |
Description | sprouty-related, EVH1 domain containing 2 |
Other Description | sprouty protein with EVH-1 domain 2, related sequence|sprouty-related, EVH1 domain-containing protein 2 |
Swissprots | D6W5F7 A1L3V4 Q2NKX6 B7Z5K7 Q7Z698 E9PEP0 |
Accessions | EAW99904 EAW99905 EAW99906 Q7Z698 AF052178 AK025550 AK056479 BAG51727 AK299079 BAH12943 AK307714 AY299090 AAP59415 BC029300 BC111495 AAI11496 BC130292 AAI30293 BC136334 AAI36335 DA102390 DC335282 HQ258249 ADR83003 XM_005264200 XP_005264257 XM_005264201 XP_005264258 XM_005264202 XP_005264259 XM_006711966 XP_006712029 NM_001128210 NP_001121682 NM_181784 NP_861449 |
Function | Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. |
Subcellular Location | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. |
Tissue Specificity | Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269|PubMed:15580519}. |
Top Pathways | Jak-STAT signaling pathway |
SPRED2 CRISPR/Cas9 KO Plasmid (h) - sc-404738 from Santa Cruz Biotechnology
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SPRED2 HDR Plasmid (h) - sc-404738-HDR from Santa Cruz Biotechnology
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SPRED2 Double Nickase Plasmid (h) - sc-404738-NIC from Santa Cruz Biotechnology
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SPRED2 Double Nickase Plasmid (h2) - sc-404738-NIC-2 from Santa Cruz Biotechnology
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SPRED2 CRISPR Activation Plasmid (h) - sc-404738-ACT from Santa Cruz Biotechnology
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SPRED2 CRISPR Activation Plasmid (h2) - sc-404738-ACT-2 from Santa Cruz Biotechnology
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SPRED2 Lentiviral Activation Particles (h) - sc-404738-LAC from Santa Cruz Biotechnology
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SPRED2 Lentiviral Activation Particles (h2) - sc-404738-LAC-2 from Santa Cruz Biotechnology
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SPRED2 siRNA (h) - sc-94969 from Santa Cruz Biotechnology
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SPRED2 shRNA Plasmid (h) - sc-94969-SH from Santa Cruz Biotechnology
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SPRED2 shRNA (h) Lentiviral Particles - sc-94969-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20514 from Sigma-Aldrich
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SPRED2 siRNA (Human) - CRJ6259 from Cohesion Biosciences
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SPRED2 RNAi - H00200734-R01 from Novus Biologicals
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SPRED2 - MBS8240889 from MyBioSource
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shRNA set against Human Spred2 (NM_181784.2) - SHH417188 from Creative biogene
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Human SPRED2 siRNA - orb276760 from Biorbyt
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SPRED2 shRNA Plasmid (Human) - CHJ6259 from Cohesion Biosciences
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