Gene Symbol | SPRED2 |
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Entrez Gene | 200734 |
Alt Symbol | Spred-2 |
Species | Human |
Gene Type | protein-coding |
Description | sprouty-related, EVH1 domain containing 2 |
Other Description | sprouty protein with EVH-1 domain 2, related sequence|sprouty-related, EVH1 domain-containing protein 2 |
Swissprots | D6W5F7 A1L3V4 Q2NKX6 B7Z5K7 Q7Z698 E9PEP0 |
Accessions | EAW99904 EAW99905 EAW99906 Q7Z698 AF052178 AK025550 AK056479 BAG51727 AK299079 BAH12943 AK307714 AY299090 AAP59415 BC029300 BC111495 AAI11496 BC130292 AAI30293 BC136334 AAI36335 DA102390 DC335282 HQ258249 ADR83003 XM_005264200 XP_005264257 XM_005264201 XP_005264258 XM_005264202 XP_005264259 XM_006711966 XP_006712029 NM_001128210 NP_001121682 NM_181784 NP_861449 |
Function | Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. |
Subcellular Location | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. |
Tissue Specificity | Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269|PubMed:15580519}. |
Top Pathways | Jak-STAT signaling pathway |
Human SPRED2 protein fragment - ab165867 from Abcam
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SPRED2 Antibody Blocking Peptide - LS-E22097 from LifeSpan Bioscience
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SPRED2 Antibody Blocking Peptide - LS-E30590 from LifeSpan Bioscience
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Recombinant Human SPRED2 Protein - H00200734-Q01 from Novus Biologicals
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SPRED2 Blocking Peptide - NBP1-76342PEP from Novus Biologicals
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SPRED2 Peptide - GTX85025-PEP from GeneTex
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SPRED2 Blocking Peptide - 33R-6713 from Fitzgerald
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SPRED2 - H00200734-Q01-10 from Acris Antibodies
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SPRED2 - H00200734-Q01-25 from Acris Antibodies
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SPRED2 Control Peptide - AP30823CP-N from Acris Antibodies
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Spred2 Peptide - 4849P from ProSci
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SPRED2 fusion protein - Ag21359 from Proteintech Group
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Recombinant Sprouty Related, EVH1 Domain Containing Protein 2 (SPRED2) - RPL016Hu01 from Uscn Life Science Inc.
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Recombinant Human Sprouty-related, EVH1 domain-containing protein 2(SPRED2) - CSB-YP800221HU CSB-EP800221HU CSB-BP800221HU CSB-MP800221HU from Cusabio
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SPRED2 Protein - abx163183 from Abbexa
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SPRED2-Antibody-C-term-Blocking-Peptide - BP2732b from Abgent, a WuXi AppTec company
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SPRED2 Peptide, Human - M34GP15090H from Creative Peptides
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SPRED2 Recombinant Protein (OPCD07163) - OPCD07163 from Aviva Systems Biology
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Sprouty-related, EVH1 domain-containing protein 2 (SPRED2), Recombinant Protein - MBS1359985 from MyBioSource
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