| Gene Symbol |
RNF43
|
| Entrez Gene |
54894
|
| Alt Symbol |
RNF124, URCC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 43
|
| Other Description |
E3 ubiquitin-protein ligase RNF43
|
| Swissprots |
B7Z5D5 Q68DV7 B7Z443 B7Z5J5 Q65ZA4 Q6AI04 Q9NXD0 A8K4R2
|
| Accessions |
EAW94458 EAW94459 Q68DV7 AB081837 BAD51435 AK000322 BAA91085 AK291027 BAF83716 AK296769 BAH12429 AK298789 BAH12871 AK299024 BAH12931 AK309297 BC109028 AAI09029 CR627423 CAH10510 CR749257 CAH18113 DA457410 DA723235 XM_011524954 XP_011523256 XM_011524955 XP_011523257 XM_011524956 XP_011523258 NM_001305544 NP_001292473 NM_001305545 NP_001292474 NM_017763 NP_060233
|
| Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
|
| Tissue Specificity |
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269|PubMed:15492824, ECO:0000269|PubMed:18313049}.
|