RNF43

Gene Symbol	RNF43
Entrez Gene	54894
Alt Symbol	RNF124, URCC
Species	Human
Gene Type	protein-coding
Description	ring finger protein 43
Other Description	E3 ubiquitin-protein ligase RNF43
Swissprots	B7Z5D5 Q68DV7 B7Z443 B7Z5J5 Q65ZA4 Q6AI04 Q9NXD0 A8K4R2
Accessions	EAW94458 EAW94459 Q68DV7 AB081837 BAD51435 AK000322 BAA91085 AK291027 BAF83716 AK296769 BAH12429 AK298789 BAH12871 AK299024 BAH12931 AK309297 BC109028 AAI09029 CR627423 CAH10510 CR749257 CAH18113 DA457410 DA723235 XM_011524954 XP_011523256 XM_011524955 XP_011523257 XM_011524956 XP_011523258 NM_001305544 NP_001292473 NM_001305545 NP_001292474 NM_017763 NP_060233
Function	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
Tissue Specificity	Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269|PubMed:15492824, ECO:0000269|PubMed:18313049}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNF43 Blocking Peptide - LS-E2270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF43 Antibody Blocking Peptide - LS-E15905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF43-Antibody-C-term-Blocking-Peptide - BP13204b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human RNF43 Fc Chimera, CF - 7964-RN-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived

Human RNF43 (His Tag) protein - orb179569 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

RNF43 Blocking Peptide - 33R-1926 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF43 fusion protein - Ag24736 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

Recombinant Human RNF43, Fc-tagged - RNF43-385H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human RNF43, His-tagged - RNF43-386H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human RNF43 - RNF43-1145H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Human RNF43 Protein (Fc Tag) - 16108-H02H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human RNF43 Protein (His Tag) - 16108-H08H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Human RING finger protein 43(RNF43) - CSB-YP019892HU CSB-EP019892HU CSB-BP019892HU CSB-MP019892HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human RNF43 Fc Chimera Protein, CF - 7964-RN from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived Human RNF43 (Glu43-Val199) Accession # Q68DV7 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

Recombinant Human RNF43 Protein (His tag) - PKSH030501 from Elabscience Category Protein Source Human Cells Species Human

Recombinant Human RNF43 Protein, Fc-tagged - RNF43-767H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human RNF43 Protein, His-tagged - RNF43-768H from Creative Biomart Category Protein Source HEK293 Species Human

RNF43 Recombinant Protein Antigen - NBP1-85018PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human RNF43 (Fc Tag) protein - orb179568 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

RNF43 Peptide, Human - M34GP13440H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human RNF43 Protein (Fc Tag) - 16108-H02H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human RNF43 Protein (His Tag) - 16108-H08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

RING finger protein 43 (RNF43), Recombinant Protein - MBS1325922 from MyBioSource Category Protein Prices $920.00, $920.00, $1,140.00, $1,140.00, $1,365.00, $1,365.00, $1,820.00, $1,820.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RNF43, Recombinant Protein - MBS2545196 from MyBioSource Category Protein Prices $475.00, $775.00 Sizes 50 µg, 100 µg Source Human Cells

Recombinant Human RNF43 Fc Chimera Protein, CF - 7964-RN from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg Species Human

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