RNF43

Gene Symbol RNF43
Entrez Gene 54894
Alt Symbol RNF124, URCC
Species Human
Gene Type protein-coding
Description ring finger protein 43
Other Description E3 ubiquitin-protein ligase RNF43
Swissprots B7Z5D5 Q68DV7 B7Z443 B7Z5J5 Q65ZA4 Q6AI04 Q9NXD0 A8K4R2
Accessions EAW94458 EAW94459 Q68DV7 AB081837 BAD51435 AK000322 BAA91085 AK291027 BAF83716 AK296769 BAH12429 AK298789 BAH12871 AK299024 BAH12931 AK309297 BC109028 AAI09029 CR627423 CAH10510 CR749257 CAH18113 DA457410 DA723235 XM_011524954 XP_011523256 XM_011524955 XP_011523257 XM_011524956 XP_011523258 NM_001305544 NP_001292473 NM_001305545 NP_001292474 NM_017763 NP_060233
Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
Tissue Specificity Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269|PubMed:15492824, ECO:0000269|PubMed:18313049}.

RNF43 CRISPR/Cas9 KO Plasmid (h) - sc-403797 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 HDR Plasmid (h) - sc-403797-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 Double Nickase Plasmid (h) - sc-403797-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 Double Nickase Plasmid (h2) - sc-403797-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 CRISPR Activation Plasmid (h) - sc-403797-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 CRISPR Activation Plasmid (h2) - sc-403797-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 Lentiviral Activation Particles (h) - sc-403797-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 Lentiviral Activation Particles (h2) - sc-403797-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF43 siRNA (h) - sc-94164 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF43 shRNA Plasmid (h) - sc-94164-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF43 shRNA (h) Lentiviral Particles - sc-94164-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF43 RNAi - H00054894-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU058181 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18438 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18438 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RNF43 siRNA (Human) - CRJ0304 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF43 - MBS8237874 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF43 (NM_017763.4) - SHH397372 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RNF43(NM_017763.4) - SHR187464 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF43 siRNA - orb270805 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF43 shRNA Plasmid (Human) - CHJ0304 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF43 miRNA 3'UTR clone - MiUTR1H-08905 from Creative biogene

Species Reactivities Human
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