| Gene Symbol |
POLR1E
|
| Entrez Gene |
64425
|
| Alt Symbol |
PAF53, PRAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) I polypeptide E, 53kDa
|
| Other Description |
DNA-directed RNA polymerase I subunit E|DNA-directed RNA polymerase I subunit RPA49|RNA polymerase I subunit A49|RNA polymerase I-associated factor 53|polymerase (RNA) I associated factor 1
|
| Swissprots |
Q5VZT3 Q96L20 Q8NBA9 Q9GZS1
|
| Accessions |
EAW58280 EAW58281 Q9GZS1 AK023452 BAB14579 AK024032 BAB14791 AK091294 BAC03629 AK125471 AK225050 AK301347 BAG62895 AK302345 BAG63673 AK303167 BAG64267 BC001337 AAH01337 BC009757 BC014180 BC014331 AAH14331 BC017766 CR457313 CAG33594 XM_005251547 XP_005251604 NM_001282766 NP_001269695 NM_022490 NP_071935
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Top Pathways |
Purine metabolism, RNA polymerase, Pyrimidine metabolism
|