Gene Symbol | POLR1E |
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Entrez Gene | 64425 |
Alt Symbol | PAF53, PRAF1 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) I polypeptide E, 53kDa |
Other Description | DNA-directed RNA polymerase I subunit E|DNA-directed RNA polymerase I subunit RPA49|RNA polymerase I subunit A49|RNA polymerase I-associated factor 53|polymerase (RNA) I associated factor 1 |
Swissprots | Q5VZT3 Q96L20 Q8NBA9 Q9GZS1 |
Accessions | EAW58280 EAW58281 Q9GZS1 AK023452 BAB14579 AK024032 BAB14791 AK091294 BAC03629 AK125471 AK225050 AK301347 BAG62895 AK302345 BAG63673 AK303167 BAG64267 BC001337 AAH01337 BC009757 BC014180 BC014331 AAH14331 BC017766 CR457313 CAG33594 XM_005251547 XP_005251604 NM_001282766 NP_001269695 NM_022490 NP_071935 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. |
Top Pathways | Purine metabolism, RNA polymerase, Pyrimidine metabolism |
POLR1E CRISPR/Cas9 KO Plasmid (h) - sc-407602 from Santa Cruz Biotechnology
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POLR1E HDR Plasmid (h) - sc-407602-HDR from Santa Cruz Biotechnology
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POLR1E Double Nickase Plasmid (h) - sc-407602-NIC from Santa Cruz Biotechnology
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POLR1E Double Nickase Plasmid (h2) - sc-407602-NIC-2 from Santa Cruz Biotechnology
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POLR1E CRISPR Activation Plasmid (h) - sc-407602-ACT from Santa Cruz Biotechnology
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POLR1E CRISPR Activation Plasmid (h2) - sc-407602-ACT-2 from Santa Cruz Biotechnology
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POLR1E Lentiviral Activation Particles (h) - sc-407602-LAC from Santa Cruz Biotechnology
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POLR1E Lentiviral Activation Particles (h2) - sc-407602-LAC-2 from Santa Cruz Biotechnology
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POLR1E siRNA (h) - sc-92929 from Santa Cruz Biotechnology
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POLR1E shRNA Plasmid (h) - sc-92929-SH from Santa Cruz Biotechnology
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POLR1E shRNA (h) Lentiviral Particles - sc-92929-V from Santa Cruz Biotechnology
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PRAF1 RNAi - H00064425-R01 from Novus Biologicals
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MISSION® esiRNA - EHU133311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17110 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17110 from Sigma-Aldrich
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POLR1E siRNA (Human) - CRJ2020 from Cohesion Biosciences
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shRNA set against Human POLR1E (NM_022490.1) - SHH379364 from Creative biogene
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shRNA set against Human POLR1E(NM_022490.1) - SHR127336 from Creative biogene
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Human POLR1E siRNA - orb272521 from Biorbyt
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POLR1E shRNA Plasmid (Human) - CHJ2020 from Cohesion Biosciences
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POLR1E miRNA 3'UTR clone - MiUTR1H-08071 from Creative biogene
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