| Gene Symbol |
ZFYVE9
|
| Entrez Gene |
9372
|
| Alt Symbol |
MADHIP, NSP, PPP1R173, SARA, SMADIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 9
|
| Other Description |
MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor|MADH-interacting protein|novel serine protease|protein phosphatase 1, regulatory subunit 173|smad anchor for receptor activation|zinc finger FYVE domain-containing protein 9
|
| Swissprots |
Q5T0F7 Q9Y5R7 O95405 Q9UNE1 Q5T0F6
|
| Accessions |
CCQ43282 EAX06790 EAX06791 EAX06792 O95405 AB209125 BAD92362 AF104304 AAC99462 AF130419 AAD31694 AF130420 AAD31695 BC032680 AAH32680 DR005493 EU176568 ABW03369 XM_011542437 XP_011540739 NM_004799 NP_004790 NM_007324 NP_015563 NM_007323
|
| Function |
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}.
|
| Subcellular Location |
Cytoplasm. Early endosome membrane.
|
| Tissue Specificity |
Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
|
| Top Pathways |
TGF-beta signaling pathway, Endocytosis
|
![Western Blot: ZFYVE9 Overexpression Lysate (Adult Normal) [NBL1-18029] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZFYVE9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5664_ZFYVE9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-18029-img0002.jpg)
![Western Blot: ZFYVE9 Overexpression Lysate (Adult Normal) [NBP2-09843] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZFYVE9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2849_ZFYVE9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09843-img0001.jpg)