| Gene Symbol |
CCL16
|
| Entrez Gene |
6360
|
| Alt Symbol |
CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 16
|
| Other Description |
C-C motif chemokine 16|IL-10-inducible chemokine|chemokine LEC|liver CC chemokine-1|liver-expressed chemokine|lymphocyte and monocyte chemoattractant|monotactin-1|new CC chemokine 4|small inducible cytokine subfamily A (Cys-Cys), member 16|small-inducible cytokine A16
|
| Swissprots |
Q4KKU0 O15467
|
| Accessions |
AAC63330 AAC97450 BAA35138 EAW80114 O15467 AB007454 BAA24057 AF039955 AAC97451 AF055467 AAC28844 BC096352 BC099662 AAH99662 BC099663 BC099664 BQ722834 U91746 AAC05587 XM_005258020 XP_005258077 XM_006725334 XP_006725397 NM_004590 NP_004581
|
| Function |
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: LEC Overexpression Lysate (Adult Normal) [NBL1-08846] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LEC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12284_LEC%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08846-img0002.jpg)