| Gene Symbol | Htr1b |
|---|---|
| Entrez Gene | 15551 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1B |
| Other Description | 5-HT-1B|5-HT1B receptor|5-HT<1B> receptor|5-hydroxytryptamine receptor 1B|serotonin receptor 1B |
| Swissprots | P28334 |
| Accessions | AAA83221 CAA77678 EDL26441 P28334 BC119129 AAI19130 BC131951 AAI31952 NM_010482 NP_034612 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10651141, ECO:0000269|PubMed:1557407, ECO:0000269|PubMed:16750486, ECO:0000269|PubMed:8091214, ECO:0000269|PubMed:8742487, ECO:0000269|PubMed:9349547}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:1557407}; Multi-pass membrane protein {ECO:0000269|PubMed:1557407}. |
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. {ECO:0000269|PubMed:1557407}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
Mouse Htr1b cDNA clone(NM_010482.1) - CDFL005949 from Creative Biomart
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Mouse Htr1b ORF Clone(NM_010482.1) - CDCR249070 from Creative Biomart
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Mouse Htr1b ORF Clone(NM_010482.1) - CDCR249071 from Creative Biomart
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Mouse Htr1b ORF Clone(NM_010482.1) - CDCL166649 from Creative Biomart
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Mouse HTR1B ORF clone(NM_010482.1) - CDCH386372 from Creative Biomart
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Human Htr1b ORF clone (NM_010482.1) - CDCL118865 from Creative biogene
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Mouse Htr1b cDNA Clone(NM_010482.1) - CDFL005949 from Creative biogene
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