| Gene Symbol | Htr1b |
|---|---|
| Entrez Gene | 15551 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1B |
| Other Description | 5-HT-1B|5-HT1B receptor|5-HT<1B> receptor|5-hydroxytryptamine receptor 1B|serotonin receptor 1B |
| Swissprots | P28334 |
| Accessions | AAA83221 CAA77678 EDL26441 P28334 BC119129 AAI19130 BC131951 AAI31952 NM_010482 NP_034612 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10651141, ECO:0000269|PubMed:1557407, ECO:0000269|PubMed:16750486, ECO:0000269|PubMed:8091214, ECO:0000269|PubMed:8742487, ECO:0000269|PubMed:9349547}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:1557407}; Multi-pass membrane protein {ECO:0000269|PubMed:1557407}. |
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. {ECO:0000269|PubMed:1557407}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1B CRISPR/Cas9 KO Plasmid (m) - sc-420990 from Santa Cruz Biotechnology
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SR-1B HDR Plasmid (m) - sc-420990-HDR from Santa Cruz Biotechnology
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SR-1B Double Nickase Plasmid (m) - sc-420990-NIC from Santa Cruz Biotechnology
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SR-1B Double Nickase Plasmid (m2) - sc-420990-NIC-2 from Santa Cruz Biotechnology
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SR-1B CRISPR Activation Plasmid (m) - sc-420990-ACT from Santa Cruz Biotechnology
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SR-1B CRISPR Activation Plasmid (m2) - sc-420990-ACT-2 from Santa Cruz Biotechnology
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SR-1B Lentiviral Activation Particles (m) - sc-420990-LAC from Santa Cruz Biotechnology
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SR-1B Lentiviral Activation Particles (m2) - sc-420990-LAC-2 from Santa Cruz Biotechnology
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SR-1B siRNA (m) - sc-42224 from Santa Cruz Biotechnology
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SR-1B shRNA Plasmid (m) - sc-42224-SH from Santa Cruz Biotechnology
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SR-1B shRNA (m) Lentiviral Particles - sc-42224-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU044151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33545 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33545 from Sigma-Aldrich
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HTR1B siRNA (Mouse) - CRM1959 from Cohesion Biosciences
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HTR1B - MBS8208930 from MyBioSource
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shRNA set against Mouse HTR1B (NM_010482.1) - SHH315877 from Creative biogene
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shRNA set against Mouse Htr1b(NM_010482.1) - SHH135461 from Creative biogene
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Mouse HTR1B siRNA - orb281435 from Biorbyt
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HTR1B shRNA Plasmid (Mouse) - CHM1959 from Cohesion Biosciences
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HTR1B miRNA 3'UTR clone - MiUTR1M-05843 from Creative biogene
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