| Gene Symbol | Htr1b |
|---|---|
| Entrez Gene | 15551 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1B |
| Other Description | 5-HT-1B|5-HT1B receptor|5-HT<1B> receptor|5-hydroxytryptamine receptor 1B|serotonin receptor 1B |
| Swissprots | P28334 |
| Accessions | AAA83221 CAA77678 EDL26441 P28334 BC119129 AAI19130 BC131951 AAI31952 NM_010482 NP_034612 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10651141, ECO:0000269|PubMed:1557407, ECO:0000269|PubMed:16750486, ECO:0000269|PubMed:8091214, ECO:0000269|PubMed:8742487, ECO:0000269|PubMed:9349547}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:1557407}; Multi-pass membrane protein {ECO:0000269|PubMed:1557407}. |
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. {ECO:0000269|PubMed:1557407}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
Serotonin receptor 1B (HTR1B) Control Peptide - AP09879CP-N from Acris Antibodies
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5-hydroxytryptamine receptor 1B (Htr1b), Recombinant Protein - MBS964264 from MyBioSource
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Recombinant Mouse HTR1B Protein - HTR1B-7929M from Creative Biomart
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5-hydroxytryptamine receptor 1B (Htr1b), Recombinant Protein - MBS7017260 from MyBioSource
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