| Gene Symbol |
PDE2A
|
| Entrez Gene |
5138
|
| Alt Symbol |
CGS-PDE, PDE2A1, PED2A4, cGSPDE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 2A, cGMP-stimulated
|
| Other Description |
cGMP-dependent 3',5'-cyclic phosphodiesterase|cGMP-stimulated phosphodiesterase 1|cGMP-stimulated phosphodiesterase 4|cyclic GMP-stimulated phosphodiesterase
|
| Swissprots |
Q5J791 O00408 Q6ZMR1 E9PGI1 B3KRV5 Q5J793 B2R646 F6W5Z0 Q5J792
|
| Accessions |
CCQ43186 EAW74861 EAW74862 O00408 AI498038 AK092278 BAG52517 AK095024 BAG52972 AK131525 BAD18664 AK295676 BAG58533 AK312434 BAG35343 AY495087 AAS75513 AY495088 AAS75514 AY495089 AAS75515 BC040974 AAH40974 BI760519 DA219662 DA227593 DA243617 DA325165 DA329075 DA332549 DA504595 DA801834 DB068707 U67733 AAC51320 XM_005274040 XP_005274097 XM_011545096 XP_011543398 NM_001143839 NP_001137311 NM_001146209 NP_001139681 NM_001243784 NP_001230713 NM_002599 NP_002590
|
| Function |
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
|
| Subcellular Location |
Isoform PDE2A1: Cytoplasm {ECO:0000269|PubMed:19632989}.
|
| Tissue Specificity |
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
Morphine addiction, cGMP-PKG signaling pathway, Purine metabolism
|
![Western Blot: PDE2A Overexpression Lysate (Adult Normal) [NBL1-14216] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE2A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18972_PDE2A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14216-img0002.jpg)