Gene Symbol | PDE2A |
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Entrez Gene | 5138 |
Alt Symbol | CGS-PDE, PDE2A1, PED2A4, cGSPDE |
Species | Human |
Gene Type | protein-coding |
Description | phosphodiesterase 2A, cGMP-stimulated |
Other Description | cGMP-dependent 3',5'-cyclic phosphodiesterase|cGMP-stimulated phosphodiesterase 1|cGMP-stimulated phosphodiesterase 4|cyclic GMP-stimulated phosphodiesterase |
Swissprots | Q5J791 O00408 Q6ZMR1 E9PGI1 B3KRV5 Q5J793 B2R646 F6W5Z0 Q5J792 |
Accessions | CCQ43186 EAW74861 EAW74862 O00408 AI498038 AK092278 BAG52517 AK095024 BAG52972 AK131525 BAD18664 AK295676 BAG58533 AK312434 BAG35343 AY495087 AAS75513 AY495088 AAS75514 AY495089 AAS75515 BC040974 AAH40974 BI760519 DA219662 DA227593 DA243617 DA325165 DA329075 DA332549 DA504595 DA801834 DB068707 U67733 AAC51320 XM_005274040 XP_005274097 XM_011545096 XP_011543398 NM_001143839 NP_001137311 NM_001146209 NP_001139681 NM_001243784 NP_001230713 NM_002599 NP_002590 |
Function | Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. |
Subcellular Location | Isoform PDE2A1: Cytoplasm {ECO:0000269|PubMed:19632989}. |
Tissue Specificity | Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. |
Top Pathways | Morphine addiction, cGMP-PKG signaling pathway, Purine metabolism |
PDE2A CRISPR/Cas9 KO Plasmid (h) - sc-401957 from Santa Cruz Biotechnology
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PDE2A HDR Plasmid (h) - sc-401957-HDR from Santa Cruz Biotechnology
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PDE2A Double Nickase Plasmid (h) - sc-401957-NIC from Santa Cruz Biotechnology
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PDE2A Double Nickase Plasmid (h2) - sc-401957-NIC-2 from Santa Cruz Biotechnology
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PDE2A CRISPR Activation Plasmid (h) - sc-401957-ACT from Santa Cruz Biotechnology
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PDE2A CRISPR Activation Plasmid (h2) - sc-401957-ACT-2 from Santa Cruz Biotechnology
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PDE2A Lentiviral Activation Particles (h) - sc-401957-LAC from Santa Cruz Biotechnology
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PDE2A Lentiviral Activation Particles (h2) - sc-401957-LAC-2 from Santa Cruz Biotechnology
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PDE2A siRNA (h) - sc-41590 from Santa Cruz Biotechnology
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PDE2A shRNA Plasmid (h) - sc-41590-SH from Santa Cruz Biotechnology
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PDE2A shRNA (h) Lentiviral Particles - sc-41590-V from Santa Cruz Biotechnology
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PDE2A RNAi - H00005138-R01 from Novus Biologicals
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MISSION® esiRNA - EHU013911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16533 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16533 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08701 from Sigma-Aldrich
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PDE2A siRNA (Human) - CRH3418 from Cohesion Biosciences
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shRNA set against Human PDE2A (NM_002599.4) - SHH372392 from Creative biogene
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Human PDE2A siRNA - orb263920 from Biorbyt
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PDE2A shRNA Plasmid (Human) - CHH3418 from Cohesion Biosciences
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PDE2A miRNA 3'UTR clone - MiUTR3H-05193 from Creative biogene
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PDE2A miRNA 3'UTR clone - MiUTR3H-05194 from Creative biogene
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PDE2A miRNA 3'UTR clone - MiUTR3H-05195 from Creative biogene
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