| Gene Symbol |
SGK2
|
| Entrez Gene |
10110
|
| Alt Symbol |
H-SGK2, dJ138B7.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serum/glucocorticoid regulated kinase 2
|
| Other Description |
serine/threonine-protein kinase Sgk2
|
| Swissprots |
Q52PK5 Q5H8Z1 Q9UKG6 Q9HBY8 Q5TZR3 Q5H8Y6
|
| Accessions |
EAW75955 EAW75956 Q9HBY8 AF169034 AAF12757 AF186470 AAG17012 AK289596 BAF82285 AK308502 AY987010 AAX88805 BC006523 BC014037 AAH14037 BC065511 AAH65511 BG420383 BT020098 AAV38901 CD627734 DA244897 DB183229 DC385330 NM_001199264 NP_001186193 NM_016276 NP_057360 NM_170693 NP_733794
|
| Function |
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. {ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21865597}. Nucleus {ECO:0000269|PubMed:21865597}.
|
| Tissue Specificity |
Highly expressed in liver, kidney and pancreas, and at lower levels in brain. {ECO:0000269|PubMed:10548550}.
|
| Top Pathways |
PI3K-Akt signaling pathway
|