| Gene Symbol |
PAK1
|
| Entrez Gene |
5058
|
| Alt Symbol |
PAKalpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
p21 protein (Cdc42/Rac)-activated kinase 1
|
| Other Description |
STE20 homolog, yeast|alpha-PAK|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)|p65-PAK|serine/threonine-protein kinase PAK 1
|
| Swissprots |
O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79
|
| Accessions |
EAW75026 EAW75027 EAW75028 EAW75029 Q13153 AF071884 AAC24716 AK055228 BAG51489 AK293098 BAF85787 AK295344 BAH12038 AK296006 BAH12236 BC050377 BC109298 BC109299 AAI09300 BE501896 BE502192 BI793123 BM451179 DA393732 EU832767 ACE87778 GQ129310 ACT64444 U24152 AAA65441 U51120 AAC50590 XM_011545080 XP_011543382 XM_011545081 XP_011543383 XM_011545082 XP_011543384 XM_011545083 XP_011543385 XM_011545084 XP_011543386 NM_001128620 NP_001122092 NM_002576 NP_002567
|
| Function |
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1,
|
| Subcellular Location |
Cytoplasm. Cell junction, focal adhesion. Cell membrane. Cell projection, ruffle membrane. Note=Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
|
| Top Pathways |
Proteoglycans in cancer, Fc gamma R-mediated phagocytosis, Chemokine signaling pathway, cAMP signaling pathway, Axon guidance
|