PAK1

Gene Symbol	PAK1
Entrez Gene	5058
Alt Symbol	PAKalpha
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 1
Other Description	STE20 homolog, yeast|alpha-PAK|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)|p65-PAK|serine/threonine-protein kinase PAK 1
Swissprots	O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79
Accessions	EAW75026 EAW75027 EAW75028 EAW75029 Q13153 AF071884 AAC24716 AK055228 BAG51489 AK293098 BAF85787 AK295344 BAH12038 AK296006 BAH12236 BC050377 BC109298 BC109299 AAI09300 BE501896 BE502192 BI793123 BM451179 DA393732 EU832767 ACE87778 GQ129310 ACT64444 U24152 AAA65441 U51120 AAC50590 XM_011545080 XP_011543382 XM_011545081 XP_011543383 XM_011545082 XP_011543384 XM_011545083 XP_011543385 XM_011545084 XP_011543386 NM_001128620 NP_001122092 NM_002576 NP_002567
Function	Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1,
Subcellular Location	Cytoplasm. Cell junction, focal adhesion. Cell membrane. Cell projection, ruffle membrane. Note=Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Top Pathways	Proteoglycans in cancer, Fc gamma R-mediated phagocytosis, Chemokine signaling pathway, cAMP signaling pathway, Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PAK1 full length protein - ab125805 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human PAK1 full length protein - ab177574 from Abcam Category Protein Prices $606.00 Sizes 10 µg Source E. coli Species Human

Active human PAK1 protein fragment - ab95253 from Abcam Category Protein Prices $761.00 Sizes 10 µg Source E. coli Species Human

Human PAK1 full length protein - ab67946 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PAK1 full length protein - ab45162 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Phospho-PAK1T423-Antibody-Blocking-peptide - BP3414a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-PAK1T212-Antibody-Blocking-peptide - BP3328a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PAK1-Antibody-T423-Blocking-Peptide - BP7926d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK1 blocking peptide - GTX89274-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human PAK1 protein - orb244800 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PAK1 Peptide - AC21-0977-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PAK1 - H00005058-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PAK1 - H00005058-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PAK1 - H00005058-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAK1 - H00005058-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAK1 - P4740 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PAK1 - P5382 from Acris Antibodies Category Protein Prices $670.00 Sizes 10 µg Species Human

PAK1 - P5788 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PAK1 control peptide - AP10192CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

PAK1 Peptide - 46-127P from ProSci Category Peptide Species Human, Mouse, Rat

PAK1 fusion protein - Ag16102 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PAK1(Phospho-Thr212) Antibody Blocking Peptide - GWB-E90FCC from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421) Antibody Blocking Peptide - GWB-87A8CE from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human PAK1 - PAK1-30462TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PAK1, GST-tagged - PAK1-1513H from Creative Biomart Category Protein Source E.coli Species Human

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