PAK1

Gene Symbol	PAK1
Entrez Gene	5058
Alt Symbol	PAKalpha
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 1
Other Description	STE20 homolog, yeast|alpha-PAK|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)|p65-PAK|serine/threonine-protein kinase PAK 1
Swissprots	O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79
Accessions	EAW75026 EAW75027 EAW75028 EAW75029 Q13153 AF071884 AAC24716 AK055228 BAG51489 AK293098 BAF85787 AK295344 BAH12038 AK296006 BAH12236 BC050377 BC109298 BC109299 AAI09300 BE501896 BE502192 BI793123 BM451179 DA393732 EU832767 ACE87778 GQ129310 ACT64444 U24152 AAA65441 U51120 AAC50590 XM_011545080 XP_011543382 XM_011545081 XP_011543383 XM_011545082 XP_011543384 XM_011545083 XP_011543385 XM_011545084 XP_011543386 NM_001128620 NP_001122092 NM_002576 NP_002567
Function	Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1,
Subcellular Location	Cytoplasm. Cell junction, focal adhesion. Cell membrane. Cell projection, ruffle membrane. Note=Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Top Pathways	Proteoglycans in cancer, Fc gamma R-mediated phagocytosis, Chemokine signaling pathway, cAMP signaling pathway, Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PAK1 siRNA I - 6361 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PAK1 siRNA II - 6536 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

αPAK CRISPR/Cas9 KO Plasmid (h) - sc-400857 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK HDR Plasmid (h) - sc-400857-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK Double Nickase Plasmid (h) - sc-400857-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK Double Nickase Plasmid (h2) - sc-400857-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK CRISPR Activation Plasmid (h) - sc-400857-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK CRISPR Activation Plasmid (h2) - sc-400857-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK Lentiviral Activation Particles (h) - sc-400857-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK Lentiviral Activation Particles (h2) - sc-400857-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK siRNA (h) - sc-29700 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

αPAK shRNA Plasmid (h) - sc-29700-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

αPAK shRNA (h) Lentiviral Particles - sc-29700-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU140181 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1484 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1483 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1485 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1920 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1920 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08884 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08884

PAK1 siRNA (Human) - CRH3362 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

αPAK CRISPR/Cas9 KO Plasmid (h2) - sc-400857-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

αPAK HDR Plasmid (h2) - sc-400857-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human PAK1 (NM_002576.4) - SHH370136 from Creative biogene Category siRNA Species Reactivities Human

Human PAK1 siRNA - orb263864 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Search more