| Gene Symbol |
RNF125
|
| Entrez Gene |
54941
|
| Alt Symbol |
TNORS, TRAC-1, TRAC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 125, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase RNF125|T-cell RING activation protein 1|T-cell ring protein identified in activation screen
|
| Swissprots |
Q96EQ8 Q9NX39
|
| Accessions |
EAX01278 Q96EQ8 AK000463 BAA91182 AK027134 AK225518 BC012021 AAH12021 BI666910 BM469263 BU500546 XM_011526045 XP_011524347 XM_011526046 XP_011524348 XM_011526047 XP_011524349 NM_017831 NP_060301
|
| Function |
E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15843525}.
|
| Tissue Specificity |
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells. {ECO:0000269|PubMed:12974981, ECO:0000269|PubMed:15843525}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|