RNF125

Gene Symbol RNF125
Entrez Gene 54941
Alt Symbol TNORS, TRAC-1, TRAC1
Species Human
Gene Type protein-coding
Description ring finger protein 125, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase RNF125|T-cell RING activation protein 1|T-cell ring protein identified in activation screen
Swissprots Q96EQ8 Q9NX39
Accessions EAX01278 Q96EQ8 AK000463 BAA91182 AK027134 AK225518 BC012021 AAH12021 BI666910 BM469263 BU500546 XM_011526045 XP_011524347 XM_011526046 XP_011524348 XM_011526047 XP_011524349 NM_017831 NP_060301
Function E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15843525}.
Tissue Specificity Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells. {ECO:0000269|PubMed:12974981, ECO:0000269|PubMed:15843525}.
Top Pathways RIG-I-like receptor signaling pathway

TRAC-1 CRISPR/Cas9 KO Plasmid (h) - sc-409980 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 HDR Plasmid (h) - sc-409980-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 Double Nickase Plasmid (h) - sc-409980-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 Double Nickase Plasmid (h2) - sc-409980-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 CRISPR Activation Plasmid (h) - sc-409980-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 CRISPR Activation Plasmid (h2) - sc-409980-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 Lentiviral Activation Particles (h) - sc-409980-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 Lentiviral Activation Particles (h2) - sc-409980-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRAC-1 siRNA (h) - sc-76723 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAC-1 shRNA Plasmid (h) - sc-76723-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRAC-1 shRNA (h) Lentiviral Particles - sc-76723-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF125 RNAi - H00054941-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU050121 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18375 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18375 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RNF125 siRNA (Human) - CRJ0344 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF125 - MBS8217115 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF125 (NM_017831.3) - SHH396644 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RNF125(NM_017831.3) - SHR185122 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF125 siRNA - orb270845 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF125 shRNA Plasmid (Human) - CHJ0344 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF125 miRNA 3'UTR clone - MiUTR1H-08872 from Creative biogene

Species Reactivities Human
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