ATG7

Gene Symbol	ATG7
Entrez Gene	10533
Alt Symbol	APG7-LIKE, APG7L, GSA7
Species	Human
Gene Type	protein-coding
Description	autophagy related 7
Other Description	ATG12-activating enzyme E1 ATG7|ATG7 autophagy related 7 homolog|autophagy-related protein 7|hAGP7|ubiquitin activating enzyme E1-like protein|ubiquitin-activating enzyme E1-like protein|ubiquitin-like modifier-activating enzyme ATG7
Swissprots	Q9BWP2 B4E170 Q9UFH4 E9PB95 Q7L8L0 O95352
Accessions	CAF86536 EAW64093 EAW64094 EAW64095 EAW64096 EAW64097 O95352 AF094516 AAC69630 AK075221 BAG52088 AK298833 BAG60963 AK303694 BAG64682 AK314504 BAG37104 AL122075 CAB59250 BC000091 AAH00091 BP373819 DA177126 XM_006712931 XP_006712994 XM_006712932 XP_006712995 XM_006712933 XP_006712996 XM_011533277 XP_011531579 XM_011533278 XP_011531580 XM_011533279 XP_011531581 XM_011533280 XP_011531582 XM_011533281 XP_011531583 XM_011533282 XP_011531584 XM_011533283 XP_011531585 XM_011533284 XP_011531586 XM_011533285 XP_011531587 XM_011533286 XP_011531588 XR_940363 NM_001136031 NP_001129503 NM_001144912 NP_001138384 NM_006395 NP_006386
Function	E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269|PubMed:11096062, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269|PubMed:11890701}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Apg7 / ATG7 ELISA Kit (Sandwich ELISA) - LS-F9291 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Mouse Apg7 / ATG7 ELISA Kit (Sandwich ELISA) - LS-F9293 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.313-20 ng/ml

Human ATG7 ELISA Kit - abx150766 from Abbexa Category ELISA Kit Sensitivity 0.107 ng/ml Range 0.313 ng/ml - 20 ng/ml

Autophagy Related Protein 7 (ATG7), Human, ELISA Kit - SEL222Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.107ng/mL Range 0.312-20ng/mL

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), Human, ELISA Kit - CSB-EL002294HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7 pg/ml Range 28.12 pg/ml-1800 pg/ml

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), Human, ELISA Kit - E01U0034 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

ATG7 (Human) IP-WB Antibody Pair - H00010533-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Ubiquitin like modifier activating enzyme ATG7 (ATG7), ELISA Kit - MBS7208439 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7222817 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7244838 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7200806 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7240771 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7216215 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7209589 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7224971 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7253427 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7216342 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), ELISA Kit - MBS7243496 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATG7 autophagy related 7 homolog (S. cerevisiae) , ELISA Kit - MBS906789 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ATG7 is typically less than 7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 28.12 pg/ml -1800 pg/ml.

ELISA Kit for Autophagy Related Protein 7 (ATG7) - SEL222Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Autophagy Related Protein 7 (ATG7) - SEL222Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Ubiquitin-like modifier-activating enzyme ATG7(ATG7) ELISA kit - CSB-EL002294HU from Cusabio Category ELISA Kit Sensitivity 7 pg/ml. Range 28 pg/ml-1800 pg/ml

ELISA Kit for Autophagy Related Protein 7 (ATG7) - SEL222Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Autophagy Related Protein 7 (ATG7), Human, ELISA Kit - DL-ATG7-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human ATG7 ELISA Kit - abx573087 from Abbexa Category ELISA Kit Sensitivity 0.107 ng/ml Range 0.313 ng/ml - 20 ng/ml

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