ATG7

Gene Symbol	ATG7
Entrez Gene	10533
Alt Symbol	APG7-LIKE, APG7L, GSA7
Species	Human
Gene Type	protein-coding
Description	autophagy related 7
Other Description	ATG12-activating enzyme E1 ATG7|ATG7 autophagy related 7 homolog|autophagy-related protein 7|hAGP7|ubiquitin activating enzyme E1-like protein|ubiquitin-activating enzyme E1-like protein|ubiquitin-like modifier-activating enzyme ATG7
Swissprots	Q9BWP2 B4E170 Q9UFH4 E9PB95 Q7L8L0 O95352
Accessions	CAF86536 EAW64093 EAW64094 EAW64095 EAW64096 EAW64097 O95352 AF094516 AAC69630 AK075221 BAG52088 AK298833 BAG60963 AK303694 BAG64682 AK314504 BAG37104 AL122075 CAB59250 BC000091 AAH00091 BP373819 DA177126 XM_006712931 XP_006712994 XM_006712932 XP_006712995 XM_006712933 XP_006712996 XM_011533277 XP_011531579 XM_011533278 XP_011531580 XM_011533279 XP_011531581 XM_011533280 XP_011531582 XM_011533281 XP_011531583 XM_011533282 XP_011531584 XM_011533283 XP_011531585 XM_011533284 XP_011531586 XM_011533285 XP_011531587 XM_011533286 XP_011531588 XR_940363 NM_001136031 NP_001129503 NM_001144912 NP_001138384 NM_006395 NP_006386
Function	E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269|PubMed:11096062, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269|PubMed:11890701}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Atg7 (D12B11) Rabbit mAb - 8558 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D12B11

Atg7 Antibody - 2631 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

APG7 (B-9) - sc-376212 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

APG7 (H-300) - sc-33211 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

APG7 (N-20) - sc-8668 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

APG7 (K-17) - sc-12497 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Apg7 antibody - ab62112 from Abcam Host Sheep Clonality Polyclonal

Anti-Apg7 antibody - ab58735 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Apg7 antibody - ab64132 from Abcam Host Rabbit Clonality Polyclonal

Anti-Apg7 antibody - ab187348 from Abcam Host Rabbit Clonality Polyclonal

Anti-Apg7 antibody - ab89775 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Apg7 antibody [EP1759Y] - ab52472 from Abcam Prices $391.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1759Y

Anti-Apg7 antibody [EP1759Y] (Alexa Fluor® 647) - ab200876 from Abcam Prices $425.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1759Y

Anti-Apg7 antibody [EPR6251] - ab133528 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6251

Anti-Apg7 / ATG7 Antibody (aa558-569) IHC-plus™ - LS-B330 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (N-Terminus) IHC-plus™ - LS-B2217 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (C-Terminus) IHC-plus™ - LS-B2216 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (aa38-50) - LS-C188040 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody - LS-C156612 from LifeSpan Bioscience Prices $295.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-Apg7 / ATG7 Antibody (aa547-576, APC) - LS-C251508 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (aa547-576, AP) - LS-C251509 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (aa547-576, Biotin) - LS-C251510 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (aa489-538) - LS-C170299 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (aa550-600) - LS-C148584 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Apg7 / ATG7 Antibody (Internal, clone EPR6251) IHC-plus™ - LS-B6655 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EPR6251

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