ATG7

Gene Symbol	ATG7
Entrez Gene	10533
Alt Symbol	APG7-LIKE, APG7L, GSA7
Species	Human
Gene Type	protein-coding
Description	autophagy related 7
Other Description	ATG12-activating enzyme E1 ATG7|ATG7 autophagy related 7 homolog|autophagy-related protein 7|hAGP7|ubiquitin activating enzyme E1-like protein|ubiquitin-activating enzyme E1-like protein|ubiquitin-like modifier-activating enzyme ATG7
Swissprots	Q9BWP2 B4E170 Q9UFH4 E9PB95 Q7L8L0 O95352
Accessions	CAF86536 EAW64093 EAW64094 EAW64095 EAW64096 EAW64097 O95352 AF094516 AAC69630 AK075221 BAG52088 AK298833 BAG60963 AK303694 BAG64682 AK314504 BAG37104 AL122075 CAB59250 BC000091 AAH00091 BP373819 DA177126 XM_006712931 XP_006712994 XM_006712932 XP_006712995 XM_006712933 XP_006712996 XM_011533277 XP_011531579 XM_011533278 XP_011531580 XM_011533279 XP_011531581 XM_011533280 XP_011531582 XM_011533281 XP_011531583 XM_011533282 XP_011531584 XM_011533283 XP_011531585 XM_011533284 XP_011531586 XM_011533285 XP_011531587 XM_011533286 XP_011531588 XR_940363 NM_001136031 NP_001129503 NM_001144912 NP_001138384 NM_006395 NP_006386
Function	E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269|PubMed:11096062, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269|PubMed:11890701}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Apg7 full length protein - ab188687 from Abcam Category Protein Prices $682.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Human Apg7 full length protein - ab131935 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Apg7 peptide - ab89388 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Apg7 protein fragment - ab153097 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Apg7 / ATG7 Antibody Blocking Peptide - LS-E826 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E5610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E5611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E5612 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E5613 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E30180 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E30179 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Apg7 / ATG7 Antibody Blocking Peptide - LS-E21606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG7 Partial Recombinant Protein - H00010533-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ATG7 Protein - H00010533-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ATG7 Peptide - NBP1-96759 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

ATG7 Blocking Peptide - NBP1-76650PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ATG7 Blocking Peptide - NBP1-76649PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

APG7L-AntibodyD555-Blocking-peptide - BP11191a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG7-Antibody-C-term-Blocking-peptide - BP1813d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG7-Antibody-Blocking-peptide - BP1813c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG7-Antibody-Center-Blocking-peptide - BP1813b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG7-Antibody-N-term-Blocking-peptide - BP1813a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG7 Recombinant Protein - GTX48078-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

Recombinant Human His6-ATG7 Isoform 1, CF - E-318-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains an N-terminal 6-His tag

APG7L / ATG7 - H00010533-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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